ABN1365

Anti-OSTM1

from rabbit, purified by affinity chromatography

• 别名: Osteopetrosis-associated transmembrane protein 1, Chloride channel 7 beta subunit
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: human
• 物種活性（以同源性預測）: bovine (based on 100% sequence homology), baboon (based on 100% sequence homology)
• 包裝: antibody small pack of 25 μg
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• NCBI登錄號: NP_054747.2
• UniProt登錄號: Q86WC4
• 運輸包裝: ambient
• 目標翻譯後修改: unmodified
• 基因資訊: human ... OSTM1(28962)

说明

一般說明

Osteopetrosis-associated transmembrane protein 1 (UniProt: Q86WC4; also known as Chloride channel 7 beta subunit) is encoded by the OSTM1 (also known as GL) gene (Gene ID: 28962) in human. Osteopetrosis-associated transmembrane protein 1 is a single-pass type I membrane protein that is required for osteoclast and melanocyte maturation and function. It is synthesized with a signal peptide of 31 amino acids, which is cleaved to produce the mature protein. Loss of OSTM1 leads to the most severe form of osteoporosis in mice and human. Although its role in bone chemistry is well established, several studies have shown its expression in neurons, microglia, and astrocytes. OSTM1-deficiecy in the central nervous system leads to gliosis with increased astrocyte cell population and microglia activation along with retinal degeneration at 2 to 3 weeks of age in mice. (Ref.: Ref.: Heraud, C., et al. 2014. J. Biol. Chem. 289(20); 13912-25).

特異性

This rabbit polyclonal antibody detects Osteopetrosis-associated transmembrane protein 1 in human cells. It targets an epitope within 18 amino acids from the C-terminus region.

免疫原

Epitope: C-terminus

KLH-conjugated linear peptide corresponding to 18 amino acids from the C-terminus region of human Osteopetrosis-associated transmembrane protein 1 (OSTM1).

應用

Anti-OSTM1, Cat. No. ABN1365, is a highly specific rabbit polyclonal antibody that targets Osteopetrosis-associated transmembrane protein 1 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected OSTM1 in human pancreas and human liver tissues.

Research Category
Neuroscience

品質

Evaluated by Western Blotting in human liver tissue lysate.

Western Blotting Analysis: 4 µg/mL of this antibody detected OSTM1 in 20 µg of human liver tissue lysate.

標靶描述

~37 kDa observed; 37.26 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

外觀

Affinity Purified

Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, pH 7.4 with 0.05% sodium azide.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.

其他說明

Concentration: Please refer to lot specific datasheet.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1