品質等級
形狀
lyophilized
製造商/商標名
Calbiochem®
儲存條件
OK to freeze
desiccated (hygroscopic)
protect from light
溶解度
water: soluble
運輸包裝
wet ice
儲存溫度
−70°C
一般說明
A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomer mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM.
A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomere mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM. Note: 150 nmol = 285 µg.
M.W. ~1900.
生化/生理作用
Cell permeable: yes
Primary Target
Telomerase activity in cell lysates
Telomerase activity in cell lysates
Product competes with ATP.
Reversible: no
包裝
Packaged under inert gas
警告
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
序列
5′-d(TTAGGG)-3′
其他說明
Mata, J.E., et al. 1997. Toxicol. Appl. Pharmacol. 144, 189.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Molecular oncology, 15(7), 1818-1834 (2021-03-14)
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere-independent functions of human TERT have been described. In this study, we report that TERT binds directly to the TCF binding elements located
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