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Merck
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文件

581004

Sigma-Aldrich

Telomerase Inhibitor III, Sodium Salt

The Telomerase Inhibitor III, Sodium Salt controls the biological activity of Telomerase. This small molecule/inhibitor is primarily used for Cell Structure applications.

别名:

TAG-6, 5ʹ-d(TTAGGG)-3ʹ

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About This Item

分類程式碼代碼:
12352200

品質等級

形狀

lyophilized

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
desiccated (hygroscopic)
protect from light

溶解度

water: soluble

運輸包裝

wet ice

儲存溫度

−70°C

一般說明

A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomer mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM.
A short, cell-permeable hexameric phosphorothioate oligonucleotide (PS-ODN) telomere mimic that inhibits telomerase activity in cell lysates and lengthens cell doubling time in vitro and in vivo at concentrations of less than 2.5 µM. Note: 150 nmol = 285 µg.
M.W. ~1900.

生化/生理作用

Cell permeable: yes
Primary Target
Telomerase activity in cell lysates
Product competes with ATP.
Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

序列

5′-d(TTAGGG)-3′

其他說明

Mata, J.E., et al. 1997. Toxicol. Appl. Pharmacol. 144, 189.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Manuel Bernabé-García et al.
Molecular oncology, 15(7), 1818-1834 (2021-03-14)
Telomerase reverse transcriptase (TERT) maintains telomere homeostasis, thus ensuring chromosome stability and cell proliferation. In addition, several telomere-independent functions of human TERT have been described. In this study, we report that TERT binds directly to the TCF binding elements located

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