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文件

860455P

Avanti

N-C12-deoxysphingosine

Name: N-C12-deoxysphingosine
Brand: AVANTI

N-lauroyl-1-deoxysphingosine (m18:1/12:0), powder

别名:

N-dodecanoyl-1-deoxysphing-4-enine (m18:1/12:0); N-C12-1-deoxyCer; 110992

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About This Item

经验公式（希尔记法）:

C₃₀H₅₉NO₂

CAS号:

1246298-54-3

分子量:

465.79

分類程式碼代碼:

12352211

NACRES:

NA.25

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Sigma-Aldrich

C8667

胆固醇

SAFC

C1231

胆固醇、植物的

Sigma-Aldrich

P2795

植物鞘氨醇盐酸盐盐酸盐

SAFC

137672

胆固醇

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 1 mg (860455P-1mg)
pkg of 1 × 5 mg (860455P-5mg)

製造商／商標名

Avanti Research^™ - A Croda Brand 860455P

脂質類型

sphingolipids
bioactive lipids

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

N-C12-deoxysphingosine, also known as 1-deoxydihydroceramide (1-deoxyDHCer) is, the N-acylated form of 1-deoxysphinganine, a potent inhibitor of sphingolipid metabolism.

應用

N-C12-deoxysphingosine has been used as a standard in the quantitation of atypical sphingoid bases in biological samples by reverse-phase liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-MS/MS).

包裝

5 mL Amber Glass Screw Cap Vial (860455P-1mg)

5 mL Amber Glass Screw Cap Vial (860455P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

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Ceramide synthase inhibition by fumonisin B1 causes accumulation of 1-deoxysphinganine: a novel category of bioactive 1-deoxysphingoid bases and 1-deoxydihydroceramides biosynthesized by mammalian cell lines and animals.

Nicholas C Zitomer et al.

The Journal of biological chemistry, 284(8), 4786-4795 (2008-12-20)

Fumonisin B(1) (FB(1)) is a mycotoxin that inhibits ceramide synthases (CerS) and causes kidney and liver toxicity and other disease. Inhibition of CerS by FB(1) increases sphinganine (Sa), Sa 1-phosphate, and a previously unidentified metabolite. Analysis of the latter by

Analysis of 1-Deoxysphingoid Bases and Their N-Acyl Metabolites and Exploration of Their Occurrence in Some Food Materials.

Junliang Wan et al.

Journal of agricultural and food chemistry, 67(46), 12953-12961 (2019-10-23)

Most common sphingolipids are comprised of "typical" sphingoid bases (sphinganine, sphingosine, and structurally related compounds) and are produced via the condensation of l-serine with a fatty acyl-CoA by serine palmitoyltransferase. Some organisms, including mammals, also produce "atypical" sphingoid bases that

Ceramide sphingolipid signaling mediates Tumor Necrosis Factor (TNF)-dependent toxicity via caspase signaling in dopaminergic neurons.

Terina N Martinez et al.

Molecular neurodegeneration, 7, 45-45 (2012-09-15)

Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson's disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to neuroinflammatory stimuli. Chronic inhibition of soluble Tumor Necrosis Factor (TNF) with

Biodiversity of sphingoid bases ("sphingosines") and related amino alcohols.

Sarah T Pruett et al.

Journal of lipid research, 49(8), 1621-1639 (2008-05-24)

"Sphingosin" was first described by J. L. W. Thudichum in 1884 and structurally characterized as 2S,3R,4E-2-aminooctadec-4-ene-1,3-diol in 1947 by Herb Carter, who also proposed the designation of "lipides derived from sphingosine as sphingolipides." This category of amino alcohols is now

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