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化驗
97%
形狀
powder
SMILES 字串
[O-][N+](=O)c1ccc-2c(Cc3cc(ccc-23)[N+]([O-])=O)c1
InChI
1S/C13H8N2O4/c16-14(17)10-1-3-12-8(6-10)5-9-7-11(15(18)19)2-4-13(9)12/h1-4,6-7H,5H2
InChI 密鑰
IHZCVUBSTYOFSJ-UHFFFAOYSA-N
Clare L Ritter et al.
Chemical research in toxicology, 15(4), 536-544 (2002-04-16)
Nitrofluorenes are mutagenic and carcinogenic environmental pollutants arising chiefly from combustion of fossil fuels. Nitro aromatic compounds undergo nitroreduction to N-hydroxy arylamines that bind to DNA directly or after O-esterification. This study analyzes the DNA binding and adducts from the
D Malejka-Giganti et al.
Carcinogenesis, 20(10), 2017-2023 (1999-10-03)
Nitrofluorene compounds are environmental pollutants chiefly from incomplete combustion. This study examined carcinogenicities after one intramammary injection of 2-nitrofluorene (2-NF), 2, 7-dinitrofluorene (2,7-diNF) or dimethyl sulfoxide (DMSO) (solvent control) to 30-day-old and of 2-NF, 9-OH-2-NF, 9-oxo-2-NF, 2,7-diNF, 9-oxo-2,7-diNF, 2,5-dinitrofluorene, 9-oxo-2,4,7-trinitrofluorene
Danuta Malejka-Giganti et al.
International journal of cancer, 122(9), 1958-1965 (2008-01-10)
Environmental pollution with nitroaromatic compounds may pose health hazards. We have examined the tumorigenicity in female Sprague-Dawley rats of 2,7-dinitrofluorene (2,7-diNF) and 9-oxo-2,7-diNF administered by intraperitoneal (i.p.) and oral routes at 10 micromol/kg body weight, 3 times per week for
C L Ritter et al.
Chemical research in toxicology, 13(8), 793-800 (2000-08-24)
Nitrofluorenes and C-9-oxidized nitrofluorenes are widespread environmental genotoxins which may be relevant for breast cancer on the basis of their carcinogenicities, particularly of 2, 7-dinitrofluorene (2,7-diNF), for the rat mammary gland. Since their metabolism to active carcinogens may involve nitroreduction
L Möller et al.
Carcinogenesis, 14(12), 2627-2632 (1993-12-01)
The urinary mutagenicity (unconjugated forms) after administration of 2,7-dinitrofluorene (2,7-dNF) orally or i.p. was lower compared to 2-nitrofluorene (NF) administration. When partial hepatectomy (PH) was performed before i.p. administration, both substances had higher excretion of mutagens in which 2,7-dNF increased
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