STAT5B
signal transducer and activator of transcription 5B
别名:
STAT5
物种:
Human STAT5B (6777), Mouse Stat5b (20851), Rat Stat5b (25126), domestic cat STAT5B (101090663), chicken STAT5B (395556), domestic guinea pig Stat5b (100716532), naked mole-rat Stat5b (101722721), cow STAT5B (282376), sheep STAT5B (101122961), dog STAT5B (490969)
UniProtKB ID:
基因ID:
- Human(6777) Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
- Mouse(20851) signal transducer and activator of transcription 5B
- Rat(25126) signal transducer and activator of transcription 5B
- domestic cat(101090663) signal transducer and activator of transcription 5B
- chicken(395556) signal transducer and activator of transcription 5B
- domestic guinea pig(100716532) signal transducer and activator of transcription 5B
- naked mole-rat(101722721) signal transducer and activator of transcription 5B
- cow(282376) signal transducer and activator of transcription 5B
- sheep(101122961) signal transducer and activator of transcription 5B
- dog(490969) signal transducer and activator of transcription 5B
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