IDE
insulin-degrading enzyme
别名:
INSULYSIN
物种:
Human IDE (3416), Mouse Ide (15925), Rat Ide (25700), fruit fly Ide (40248), Zebrafish ide (561390), dog IDE (477768), chicken IDE (423814), sheep IDE (101104194), cow IDE (523752), Horse IDE (100071303) ...展开
UniProtKB ID:
基因ID:
- Human(3416) Summary: This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009]
- Mouse(15925) insulin degrading enzyme
- Rat(25700) insulin degrading enzyme
- fruit fly(40248) Insulin degrading metalloproteinase
- Zebrafish(561390) insulin-degrading enzyme
- dog(477768) insulin-degrading enzyme
- chicken(423814) insulin-degrading enzyme
- sheep(101104194) insulin-degrading enzyme
- cow(523752) insulin-degrading enzyme
- Horse(100071303) insulin-degrading enzyme
- domestic cat(101093646) insulin-degrading enzyme
- naked mole-rat(101706921) insulin-degrading enzyme
- domestic guinea pig(100719651) insulin-degrading enzyme
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Antibodies
货号
说明
物种反应性
应用
Anti-Insulin-degrading enzyme (IDE) antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
western blot
Anti-IDE Antibody, clone 1J8 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse, rat
应用
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-IDE, N-Terminal (97-273) Rabbit pAb, liquid, Calbiochem®,
物种反应性
hamster, human, mouse, rat
应用
Anti-IDE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
western blot
western blot
Anti-IDE antibody produced in rabbit, ,
物种反应性
human, mouse
应用
immunofluorescence
western blot
western blot