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Merck

[A heart without overspeed trip unit].

Praxis (2014-04-24)
Roman Gähwiler, Christian Templin, Thomas F Lüscher, Jelena-Rima Ghadri
ABSTRACT

We report the case of a 38-year patient who presented in our outpatient clinic for cardiac evaluation and assessment as volunteer firefighter. The patient had an asymptomatic sinustachycardia, which was diagnosed at the age of 15. After we excluded secondary etiologies, as well as a postural orthostatic tachycardia syndrome (POTS) diagnosis of inappropriate sinus tachycardia (IST) was confirmed. A metoprolol therapy was established, however to resistant tachycardia, we suggested a combined therapy of Bisoprolol and Ivabradin, which resulted successfully in normocard sinus rhythm.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Bisoprolol hemifumarate salt, ≥98% (HPLC), solid
Sigma-Aldrich
(±)-Metoprolol (+)-tartrate salt, ≥98% (titration), powder
USP
Metoprolol tartrate, United States Pharmacopeia (USP) Reference Standard
Metoprolol tartrate, European Pharmacopoeia (EP) Reference Standard
Supelco
Metoprolol tartrate solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Bisoprolol fumarate, European Pharmacopoeia (EP) Reference Standard
Bisoprolol for system suitability, European Pharmacopoeia (EP) Reference Standard
Bisoprolol for peak identification, European Pharmacopoeia (EP) Reference Standard
USP
Bisoprolol fumarate, United States Pharmacopeia (USP) Reference Standard
Supelco
Metoprolol Tartrate, Pharmaceutical Secondary Standard; Certified Reference Material