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Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease.

Cerebrospinal fluid and plasma distribution of myo-inositol and other polyols in Alzheimer disease.

Clinical chemistry (1996-02-01)

H U Shetty, H W Holloway, M B Schapiro

ABSTRACT

Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several other polyols in cerebrospinal fluid (CSF) and plasma from 10 AD subjects and 10 healthy age-matched controls by using a gas chromatographic-mass spectrometric technique. The mean CSF concentration and CSF/plasma concentration ratio of myo-inositol in AD were not significantly different from those determined in control subjects. Also, concentration profiles of other polyols were not significantly altered in AD. CSF and plasma myo-inositol concentrations were correlated in control subjects but not in AD subjects. However, a significant correlation between CSF and plasma 1,5-anhydrosorbitol (a polyol internal control) concentrations observed in control subjects was retained in AD subjects.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Molybdenum, powder, 10 μm, ≥99.95% trace metals basis

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Nickel, powder, <50 μm, 99.7% trace metals basis

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Glycine, 99%, FCC

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L-Tyrosine, FG

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Magnesium, rod, diam. 6 mm, ≥99.9% trace metals basis

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Titanium, foil, thickness 0.025 mm, 99.98% trace metals basis

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Zinc, dust, <10 μm, ≥98%

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Copper, beads, 2-8 mm, 99.9995% trace metals basis

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Molybdenum, powder, <150 μm, 99.9% trace metals basis

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Molybdenum, foil, thickness 0.025 mm, ≥99.9% trace metals basis

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Vanadium, foil, thickness 0.127 mm, 99.7% trace metals basis

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Nickel, rod, diam. 6.35 mm, ≥99.99% trace metals basis

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Titanium, wire, diam. 1.0 mm, 99.99% trace metals basis

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Nickel, foil, thickness 0.5 mm, 99.98% trace metals basis

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Nickel, wire, diam. 0.5 mm, ≥99.9% trace metals basis

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D-Sorbitol, 99% (GC)

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Copper, wire, diam. 1.0 mm, ≥99.9%

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Manganese, chips, thickness <2.0 mm, 99%

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Copper, wire, diam. 2.0 mm, 99.999% trace metals basis

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D-Sorbitol, liquid, tested according to Ph. Eur.

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Magnesium, dendritic pieces, purified by distillation, 99.998% trace metals basis

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Magnesium, turnings, reagent grade, 98%

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Cobalt, foil, thickness 0.1 mm, ≥99.99%

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Aluminum, wire, diam. 0.58 mm, ≥99.99% trace metals basis

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Aluminum, pellets, 3-8 mesh, ≥99.999% trace metals basis