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  • Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.

Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications.

Journal of controlled release : official journal of the Controlled Release Society (2010-07-21)
Janine Jansen, Mark J Boerakker, Jean Heuts, Jan Feijen, Dirk W Grijpma
ABSTRACT

Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks. The copolymerization reactions were much faster than homopolymerization of the fumarate end-groups of the macromers. The hydrophilicity of the networks could by varied by mixing NVP and VAc at different ratios. The prepared network extracts were compatible with NIH 3T3 fibroblasts. Release of vitamin B12, used as a model drug, could be tuned by varying network hydrophilicity and macromer molecular weight. A more hydrophilic and less densely crosslinked network resulted in faster release.

MATERIALS
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Supelco
Vinyl acetate solution, certified reference material, 5000 μg/mL in acetonitrile
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Sigma-Aldrich
Vinyl acetate, contains 3-20 ppm hydroquinone as inhibitor, ≥99%
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Sigma-Aldrich
1-Vinyl-2-pyrrolidinone, contains sodium hydroxide as inhibitor, ≥99%
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Vinyl acetate, European Pharmacopoeia (EP) Reference Standard
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Sigma-Aldrich
mono-Ethyl fumarate, 95%
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Sigma-Aldrich
Vinyl acetate, CP
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100 mL
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500 mL
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6 x 100 mL
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Supelco
Vinyl acetate, analytical standard
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100 mL
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CHF 66.00
500 mL
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CHF 123.00
1 L
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CHF 199.00
6 x 100 mL
In Stock
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CHF 326.00

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