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Merck

SORT1

sortilin 1

Synonyms:
Gp95, LDLCQ6, NT3
Species:
UniProtKB ID:
Gene ID:
  • Human(6272) Summary: This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins. [provided by RefSeq, Jul 2008]
  • Mouse(20661) sortilin 1
  • Rat(83576) sortilin 1
  • cow(511591) sortilin 1
  • sheep(101104538) sortilin 1
  • domestic guinea pig(100718269) sortilin 1
  • dog(479915) sortilin 1
  • domestic cat(101090199) sortilin 1
  • Horse(100061385) sortilin 1
  • chicken(100858592) sortilin 1
  • naked mole-rat(101698000) sortilin 1

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ELISA

Product Number
Description
Species
Human Sortilin ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-SORT1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
Anti-Sortilin Antibody, serum, Chemicon®,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
Monoclonal Anti-SORT1 antibody produced in mouse, Prestige Antibodies® Powered by Atlas Antibodies, clone CL6528, purified immunoglobulin, buffered aqueous glycerol solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
Anti-Sortilin Antibody, clone F11, clone F11, from mouse,
Species Reactivity
human, mouse
Application
ELISA
immunocytochemistry

immunohistochemistry

western blot
Anti-Sortilin Antibody, clone 4E3.1, clone 4E3.1, from mouse,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Sort1,
Species
mouse
MISSION® esiRNA, targeting human SORT1,
Species
human