PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
Synonyms:
PKACA
Species:
Human PRKACA (5566), Mouse Prkaca (18747), Rat Prkaca (25636), naked mole-rat Prkaca (101707235), sheep PRKACA (443094), domestic guinea pig Prkaca (100735694), dog PRKACA (403556), Horse PRKACA (100064302), cow PRKACA (282322), domestic cat PRKACA (101090494)
UniProtKB ID:
Gene ID:
- Human(5566) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(18747) protein kinase, cAMP dependent, catalytic, alpha
- Rat(25636) protein kinase, cAMP-dependent, catalytic, alpha
- naked mole-rat(101707235) protein kinase, cAMP-dependent, catalytic, alpha
- sheep(443094) protein kinase, cAMP-dependent, catalytic, alpha
- domestic guinea pig(100735694) protein kinase, cAMP-dependent, catalytic, alpha
- dog(403556) protein kinase, cAMP-dependent, catalytic, alpha
- Horse(100064302) protein kinase, cAMP-dependent, catalytic, alpha
- cow(282322) protein kinase, cAMP-dependent, catalytic, alpha
- domestic cat(101090494) protein kinase, cAMP-dependent, catalytic, alpha
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PRKACA antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-phospho-PKA α/β CAT (pThr197) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
ANTI-PKA C-ALPHA/PKA C-BETA(N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot
Anti-PRKACA (N-terminal) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, rabbit, rat, zebrafish
Application
immunohistochemistry
western blot
western blot
Anti-PKA α antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt, ≥90% (HPLC), lyophilized powder,
Species
mouse, rat, human
Proteins
Product Number
Description
Species
PKA Protein, Recombinant, 10 µg, Recombinant human full length PKA, catalytic subunit type alpha, untagged, for use in Kinase Assays.,
Species
Protein Kinase A catalytic subunit human, >90% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous glycerol solution,
Species
human