ERBB2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonyms:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Species:
Human ERBB2 (2064), Mouse Erbb2 (13866), Rat Erbb2 (24337), domestic guinea pig Erbb2 (100727657), naked mole-rat Erbb2 (101705227), Zebrafish erbb2 (386966), chicken ERBB2 (426130), dog ERBB2 (403883), domestic cat ERBB2 (751824), Horse ERBB2 (100054739) ...More
UniProtKB ID:
Gene ID:
- Human(2064) Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
- Mouse(13866) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Rat(24337) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
- domestic guinea pig(100727657) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- naked mole-rat(101705227) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Zebrafish(386966) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- chicken(426130) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- dog(403883) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- domestic cat(751824) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Horse(100054739) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- cow(505709) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- sheep(780519) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Domestic Rabbit(100009554) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1, clone TA-1, from mouse,
Species Reactivity
human
Application
flow cytometry
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Anti-c-ErbB2/c-Neu (Ab-3) Mouse mAb (3B5), lyophilized, clone 3B5, Calbiochem®,
Species Reactivity
human, mouse
Application
Anti-c-ErbB2/c-Neu (Ab-5) Mouse mAb (TA-1), liquid, clone TA-1, Calbiochem®,
Species Reactivity
human
Application
Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody, Upstate®, from rabbit,
Species Reactivity
human, rat
Application
immunocytochemistry
western blot
western blot
Anti-c-ErbB2/c-Neu (Ab-3) Mouse mAb (3B5), liquid, clone 3B5, Calbiochem®,
Species Reactivity
human, mouse
Application