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Gastro retention using polymer cocoons.

Gastro retention using polymer cocoons.

Artificial cells, nanomedicine, and biotechnology (2014-08-01)

Julien Arnold, David Hunkeler

RESUMEN

A gastro-retentive capsule has been prepared which is retained in the stomach for a period of 24h, providing a vehicle for the controlled delivery to the upper intestines. These "gastro cocoons" can resist passage through the sphincter of the stomach, and can retain a high drug payload (30%). They are made from oppositely charged polyelectrolytes and can swell to twice their initial volume. They are strong and also can resist 550 N of compressive force. They are based on filled pharmaceutical capsules which are visible to X-rays. Using ambroxol hydrochloride as a model drug linear, zero-order, release curves were obtained.

MATERIALES

Referencia del producto

Marca

Descripción del producto

Sigma-Aldrich

Acetona, ACS reagent, ≥99.5%

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Ácido clorhídrico, ACS reagent, 37%

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Acetona, suitable for HPLC, ≥99.9%

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Acetona, HPLC Plus, for HPLC, GC, and residue analysis, ≥99.9%

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Ácido clorhídrico, ACS reagent, 37%

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Ácido clorhídrico, 37 wt. % in H₂O, 99.999% trace metals basis

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Ácido clorhídrico, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., fuming, ≥37%, APHA: ≤10

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Ácido clorhídrico, 36.5-38.0%, BioReagent, for molecular biology

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Cloruro de hidrógeno solution, 2.0 M in diethyl ether

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Acetona, suitable for HPLC, ≥99.8%

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Acetona, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.5% (GC)

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Chloromethane solution, 200 μg/mL in methanol, analytical standard

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Ácido clorhídrico solution, volumetric, 0.1 M HCl (0.1N), endotoxin free

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Acetona, ACS reagent, ≥99.5%

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Ácido clorhídrico, JIS special grade, 35.0-37.0%

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Cloruro de hidrógeno solution, 1.0 M in diethyl ether

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Acetona, JIS special grade, ≥99.5%

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