- A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy.
A dual-targeting hybrid platinum(IV) prodrug for enhancing efficacy.
Chemical communications (Cambridge, England) (2012-09-27)
Haihua Xiao, Lesan Yan, Yu Zhang, Ruogu Qi, Wenliang Li, Rui Wang, Shi Liu, Yubin Huang, Yuxin Li, Xiabin Jing
PMID23012698
RESUMEN
A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.