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Merck

The enzymes of bacterial census and censorship.

Trends in biochemical sciences (2011-11-22)
Walter Fast, Peter A Tipton
RESUMEN

N-Acyl-L-homoserine lactones (AHLs) are a major class of quorum-sensing signals used by Gram-negative bacteria to regulate gene expression in a population-dependent manner, thereby enabling group behavior. Enzymes capable of generating and catabolizing AHL signals are of significant interest for the study of microbial ecology and quorum-sensing pathways, for understanding the systems that bacteria have evolved to interact with small-molecule signals, and for their possible use in therapeutic and industrial applications. The recent structural and functional studies reviewed here provide a detailed insight into the chemistry and enzymology of bacterial communication.

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Sigma-Aldrich
(S)-α-Amino-γ-butyrolactone hydrochloride, 97%
Sigma-Aldrich
α-Amino-γ-butyrolactone hydrobromide, 99%
Sigma-Aldrich
Dihydro-3-amino-2-(3H)-furanone, AldrichCPR