T7665

Tyrphostin 51

≥98%

• Sinónimos: 2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene
• Fórmula empírica (notación de Hill): C₁₃H₈N₄O₃
• Número de CAS: 126433-07-6
• Peso molecular: 268.23
• MDL number: MFCD00133903
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278756
• NACRES: NA.77

Propiedades

• biological source: synthetic (organic)
• assay: ≥98%
• form: powder
• potency: 0.8 μM IC₅₀
• solubility: DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red
• storage temp.: 2-8°C
• SMILES string: NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N
• InChI: 1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+
• InChI key: JKNOYWVMHPMBEL-UNXLUWIOSA-N
• Gene Information: human ... CDK2(1017) , EGFR(1956)

Descripción

Application

Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1.

Biochem/physiol Actions

Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

EGFR tyrosine kinase inhibitor.

Features and Benefits

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Preparation Note

5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)