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Key Documents

Certificado de origen (COO)/COA

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P0018

Pomalidomide

Name: Pomalidomide
Brand: SIGMA

≥98% (HPLC), powder, HbF inducer

Sinónimos:

1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3

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About This Item

Fórmula empírica (notación de Hill):

C₁₃H₁₁N₃O₄

Número de CAS:

19171-19-8

Peso molecular:

273.24

MDL number:

MFCD12756407

UNSPSC Code:

12352200

PubChem Substance ID:

329819974

NACRES:

NA.77

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Slide 1 of 10

1 of 10

Sigma-Aldrich

SML2283

Lenalidomide

Sigma-Aldrich

T144

(±)-Thalidomide

Sigma-Aldrich

901558

Lenalidomide

Sigma-Aldrich

924202

5-Amino-Thalidomide

Sigma-Aldrich

911690

C5 Lenalidomide

Supelco

PHR3249

Thalidomide

Sigma-Aldrich

G7641

Monosialoganglioside G_M1 from bovine brain

Sigma-Aldrich

P4543

Ácido valproico sodium salt

Sigma-Aldrich

T151

(+)-Thalidomide

Sigma-Aldrich

901496

Pomalidomide-C₆-CO₂H

product name

Pomalidomide, ≥98% (HPLC)

ligand

pomalidomide

Quality Level

100

assay

≥98% (HPLC)

form

powder

reaction suitability

reagent type: ligand

color

yellow

solubility

DMSO: ≥14 mg/mL

storage temp.

2-8°C

SMILES string

Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

InChI

1S/C13H11N3O4/c14-7-3-1-2-6-10(7)13(20)16(12(6)19)8-4-5-9(17)15-11(8)18/h1-3,8H,4-5,14H2,(H,15,17,18)

InChI key

UVSMNLNDYGZFPF-UHFFFAOYSA-N

Gene Information

human ... CRBN(51185) , CUL4A(8451) , DDB1(1642) , RBX1(9978)

Categorías relacionadas

Química y productos bioquímicos

Unidades estructurales de degradadores proteicos

Application

Pomalidomide has been used:

to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides
for apoptosis studies and intracellular calcium analysis
as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells

Biochem/physiol Actions

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Referencia del producto

Descripción

Precios

signalword

Danger

hcodes

H360D

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Slide 1 of 9

1 of 9

Sigma-Aldrich

901516

Pomalidomide-PEG₁-NH₂hydrochloride

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T151

(+)-Thalidomide

Sigma-Aldrich

H9415

5HPP-33

Sigma-Aldrich

901495

Pomalidomide-PEG₃-NH₂ hydrochloride

Sigma-Aldrich

901487

(S,S,S)-AHPC hydrochloride

Sigma-Aldrich

T150

(−)-Thalidomide

Sigma-Aldrich

901534

(S,R,S)-AHPC-C₆-CO₂H hydrochloride

Sigma-Aldrich

901523

Pomalidomide-PEG₁-Alkyne

Sigma-Aldrich

901504

Pomalidomide-PEG₃-CO₂H

Emma C Fink et al.

Blood, 132(14), 1535-1544 (2018-08-02)

Thalidomide and its derivatives, lenalidomide and pomalidomide, are clinically effective treatments for multiple myeloma and myelodysplastic syndrome with del(5q). These molecules lack activity in murine models, limiting investigation of their therapeutic activity or toxicity in vivo. Here, we report the

Synergistic Antimyeloma Activity of Dendritic Cells and Pomalidomide in a Murine Myeloma Model.

Manh-Cuong Vo et al.

Frontiers in immunology, 9, 1798-1798 (2018-08-21)

We have previously shown that immunization with tumor antigen-loaded dendritic cells (DCs) and the immunomodulating drug, lenalidomide, synergistically potentiates the enhancing antitumor immunity in a myeloma mouse model. In this study, we investigated the immunogenicity of DCs combined with pomalidomide

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.

Themistoklis M Tsarouchas et al.

Nature communications, 9(1), 4670-4670 (2018-11-09)

Spinal cord injury leads to a massive response of innate immune cells in non-regenerating mammals, but also in successfully regenerating zebrafish. However, the role of the immune response in successful regeneration is poorly defined. Here we show that inhibiting inflammation

Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects.

Yan-Rou Tsai et al.

International journal of molecular sciences, 19(10) (2018-10-24)

Due to its high oxygen demand and abundance of peroxidation-susceptible lipid cells, the brain is particularly vulnerable to oxidative stress. Induced by a redox state imbalance involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant

S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice.

Suzanne Lentzsch et al.

Cancer research, 62(8), 2300-2305 (2002-04-17)

Thalidomide has recently been shown to be useful in the treatment of multiple myeloma and may also be useful in the treatment of other hematological malignancies. We have identified a new derivative of thalidomide, S-3-[3-amino-phthalimido]-glutarimide (S-3APG) with dual activity against

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Key Documents

Pomalidomide

≥98% (HPLC), powder, HbF inducer

About This Item

Productos recomendados

Propiedades

product name

ligand

Quality Level

assay

form

reaction suitability

color

solubility

storage temp.

SMILES string

InChI

InChI key

Gene Information

Categorías relacionadas

Descripción

Application

Biochem/physiol Actions

Features and Benefits

Productos relacionados

related product

Información de seguridad

pictograms

signalword

hcodes

pcodes

Hazard Classifications

Storage Class

wgk_germany

flash_point_f

flash_point_c

Documentación

Certificados de análisis (COA)

¿Ya tiene este producto?

Los clientes también vieron

Artículos con revisión científica externa.

Servicio técnico