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Key Documents

A8556

Sigma-Aldrich

6′-Sialyllactose sodium salt

from bovine milk or colostrum, ≥97% (HPLC)

Sinónimos:

α-NeuNAc-(2→6)-β-D-Gal-(1→4)-D-Glc, 6′-N-Acetylneuraminyl-lactose sodium salt, 6′-SL

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About This Item

Fórmula lineal:
C23H38NO19Na
Número de CAS:
Peso molecular:
655.53
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

bovine milk or colostrum

assay

≥97% (HPLC)

form

powder

impurities

≤1% free N-Acetyl Neuraminic Acid
≤11% water (Karl Fischer)

color

white to off-white

solubility

water: 20 mg/mL, clear, colorless

cation traces

Na: 2.6-4.5% (anhydrous)

storage temp.

−20°C

SMILES string

[Na+].[H][C@]1(O[C@](C[C@H](O)[C@H]1NC(C)=O)(OC[C@H]2OC(O)[C@H](O)[C@@H](O)[C@@H]2O[C@@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)C([O-])=O)[C@H](O)[C@H](O)CO

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Application

6′-Sialyllactose is a compound wherein the acetylneuraminyl (NANA) unit is connected to the galactosyl unit of lactose at the 6 position. In 3′-sialylactose, this connection is at the 3 position. 3′-Sialyllactose and 6′-Sialyllactose are used to differentiate and characterize binding domains of viruses, such as influenza and rhinitis viruses, that recognize NANA capped cell surface receptors. 3′-Sialyllactose and 6′-sialylactose are used as reference compounds in analytical methods developed to measure their presence in materials such as milk and colostrums.

Other Notes

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Shuang-Xi Chen et al.
Neural regeneration research, 15(6), 1058-1065 (2019-12-12)
Oxidative stress contributes to the pathogenesis of neurodegenerative diseases. With the aim to find reagents that reduce oxidative stress, a phage display library was screened for peptides mimicking α2,6-sialyllactose (6'-SL), which is known to beneficially influence neural functions. Using Sambucus
Maria Elena Ortiz-Soto et al.
PloS one, 11(5), e0155410-e0155410 (2016-05-12)
Sialyltransferases (STs) are disulfide-containing, type II transmembrane glycoproteins that catalyze the transfer of sialic acid to proteins and lipids and participate in the synthesis of the core structure oligosaccharides of human milk. Sialic acids are found at the outermost position
Rit Bahadur Gurung et al.
Regulatory toxicology and pharmacology : RTP, 95, 182-189 (2018-03-21)
We performed a series of toxicity studies on the safety of 6'-sialyllactose (6'-SL) sodium salt as a food ingredient. 6'-SL sodium salt, up to a maximum dose of 5000 μg/plate, did not increase the number of revertant colonies in five
Sinead T Morrin et al.
Applied microbiology and biotechnology, 103(6), 2745-2758 (2019-01-28)
Nutritional intake may influence the intestinal epithelial glycome and in turn the available attachment sites for bacteria. In this study, we tested the hypothesis that bovine colostrum may influence the intestinal cell surface and in turn the attachment of commensal
Guinevere S M Kammeijer et al.
Scientific reports, 7(1), 3733-3733 (2017-06-18)
Sialylation is a glycosylation feature that occurs in different linkages at the non-reducing end of a glycan moiety, the linkage isomers are often differentially associated with various biological processes. Due to very similar physico-chemical properties, the separation of isomeric sialylated

Artículos

O-Linked glycoproteins are usually large proteins with a molecular mass of >200 kDa. Glycosylation generally occurs in high-density clusters and may represent as much as 50-80% of the overall mass.

O-Linked glycoproteins are usually large proteins with a molecular mass of >200 kDa. Glycosylation generally occurs in high-density clusters and may represent as much as 50-80% of the overall mass.

O-Linked glycoproteins are usually large proteins with a molecular mass of >200 kDa. Glycosylation generally occurs in high-density clusters and may represent as much as 50-80% of the overall mass.

O-Linked glycoproteins are usually large proteins with a molecular mass of >200 kDa. Glycosylation generally occurs in high-density clusters and may represent as much as 50-80% of the overall mass.

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