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358R-1

Sigma-Aldrich

MUM1 (EP190) Rabbit Monoclonal Primary Antibody

Sinónimos:

Multiple Myeloma Oncogene-1

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About This Item

Código UNSPSC:
12352203

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EP190, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (358R-14)
vial of 0.1 mL concentrate Research Use Only (358R-14-RUO)
vial of 0.5 mL concentrate (358R-15)
vial of 1.0 mL concentrate (358R-16)
vial of 1.0 mL concentrate Research Use Only (358R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (358R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (358R-17)
vial of 7.0 mL pre-dilute ready-to-use (358R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (358R-18-RUO)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotipo

IgG

control

diffuse large B-cell (lymphoma), plasma cell myeloma (tumor), tonsil

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic, nuclear

Información sobre el gen

human ... PWWP3A(84939)

Descripción general

Anti-MUM1 antibody labels a 50kDa, multiple myeloma oncogene-1 (MUM1) protein. MUM1 is encoded by the MUM1/IRF-4 gene, which is mapped to 6q23-25 and identified as a myeloma-associated oncogene. It is a member of the interferon regulatory factor family of transcription factors and plays an important role in the regulation of gene expression in response to signaling by interferon and other cytokines. MUM1 positive cells express the protein in the nucleus in a diffuse and microgranular pattern. However, some positivity is also observed in the cytoplasm of MUM1-expressing cells. In normal/reactive lymphoid tissues, such as lymph node, this antibody stains plasma cells, some B-cells in the light zone of germinal centers, and a subset of T-cells (T-cells in germinal centers and interfollicular areas). MUM1 expression has been described in diffuse large B-cell lymphoma (DLBCL). Anti-MUM1 antibody can stain other B-cell lymphomas such as lymphoplasmacytic lymphoma, chronic lymphocytic leukemia, follicular lymphoma, marginal zone lymphoma, lymphoblastic lymphoma/leukemia, primary effusion lymphoma, DLBCL, Burkitt-like lymphoma, and classical Hodgkin lymphoma. However, the tumor cells in nodular lymphocyte predominant Hodgkin lymphoma are negative or only weakly positive. MUM1 is also expressed in plasma cell myeloma.

Calidad


IVD

IVD

IVD

RUO

Ligadura / enlace

MUM1 Positive Control Slides, Product No. 358S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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T Yamagata et al.
Molecular and cellular biology, 16(4), 1283-1294 (1996-04-01)
We have isolated a novel cDNA clone encoding interferon (IFN) consensus sequence-binding protein in adult T-cell leukemia cell line or activated T cells (ICSAT); this protein is the human homolog of the recently cloned Pip/LSIRF. ICSAT is structurally most closely
W Kempf et al.
The British journal of dermatology, 158(6), 1280-1287 (2008-04-16)
Primary cutaneous CD30+ lymphoproliferative disorders include lymphomatoid papulosis (LyP) and primary cutaneous CD30+ anaplastic large T-cell lymphoma (ALCL). Because of overlapping histological features, it is impossible to distinguish ALCL from LyP on histological grounds. MUM1 (Multiple Myeloma oncogene 1) is
Gabriela Gualco et al.
Human pathology, 40(4), 565-571 (2009-01-16)
Burkitt lymphoma is a highly aggressive non-Hodgkin lymphoma with endemic, sporadic, and immunodeficiency-associated clinical variants composed of monomorphic medium-sized B cells with a high proliferation rate and a translocation involving the C-MYC locus. Classically, the immunophenotype of Burkitt lymphoma has
Antonino Carbone et al.
British journal of haematology, 117(2), 366-372 (2002-04-26)
Biological and clinical studies have shown that Hodgkin's disease (HD) can be divided into two major categories, termed nodular lymphocyte predominance HD (NLP HD) and classic HD (CHD). Within CHD four subtypes have been distinguished: nodular sclerosis, mixed cellularity, lymphocyte
Uma Sundram et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 16(8), 802-810 (2003-08-16)
The diagnosis of malignant melanoma remains one of the most difficult to render in surgical pathology, partially because of its extreme histologic variability. Limits in the sensitivity and/or specificity of the currently available melanocytic markers such as anti-S100, HMB45, and

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