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T63002

Sigma-Aldrich

2,2,2-Trifluoroethanol

ReagentPlus®, ≥99%

Sinónimos:

Trifluoroethyl alcohol

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About This Item

Fórmula lineal:
CF3CH2OH
Número de CAS:
75-89-8
Peso molecular:
100.04
Beilstein/REAXYS Number:
1733203
EC Number:
200-913-6
MDL number:
MFCD00004672
UNSPSC Code:
12191601
PubChem Substance ID:
329826635
NACRES:
NA.21

vapor density

3.5 (vs air)

vapor pressure

70 mmHg ( 25 °C)

product line

ReagentPlus®

assay

≥99%

form

liquid

autoignition temp.

~896 °F

expl. lim.

42 %

refractive index

n20/D 1.3 (lit.)

pH

7

bp

77-80 °C (lit.)

mp

−44 °C (lit.)

density

1.373 g/mL at 25 °C (lit.)

SMILES string

OCC(F)(F)F

InChI

1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2

InChI key

RHQDFWAXVIIEBN-UHFFFAOYSA-N

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General description

2,2,2-Trifluoroethanol (TFE) is an organic compound with the chemical formula CF3CH2OH. TFE is a commonly used solvent in organic synthesis. It can also be used as a cosolvent in the experimental study of proteins and peptides.

Application

2,2,2-Trifluoroethanol can be used as a solvent:
  • In the synthesis of 2-amino-3-cyano-4H-chromene and tetrahydrobenzo[b]pyran derivatives by catalyst free one-pot condensation of aldehydes, malononitrile and resorcinol or dimedone.
  • In the N-formylation of amines with formic acid in the presence of heterogeneous ZIF-8 (zeolitic imidazolate framework) catalyst.
  • In the preparation of 2-substituted-2,3-dihydro-4(1H)-quinazolinone derivatives by condensation of anthranilamide with alkyl, aryl, or heteroaryl ketones or aldehydes.
  • In the mild and selective oxidation of sulfur compounds using H2O2(hydrogen peroxide).

Features and Benefits

2,2,2-Trifluoroethanol is more acidic than ethanol due to the presence of electronegative trifluoromethyl group.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Flam. Liq. 3 - Repr. 1B - STOT RE 2 Inhalation

target_organs

Blood

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

86.0 °F - closed cup

flash_point_c

30 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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