T4885

Trichloroacetic acid

≥99.0% (titration)

• Sinónimos: TCA
• Fórmula lineal: Cl₃CCOOH
• Número de CAS: 76-03-9
• Peso molecular: 163.39
• Beilstein/REAXYS Number: 970119
• EC Number: 200-927-2
• MDL number: MFCD00004177
• UNSPSC Code: 12352100
• PubChem Substance ID: 24900233
• NACRES: NA.21

Propiedades

• vapor density: <1 (vs air)
• Quality Level: 200
• vapor pressure: 1 mmHg ( 51 °C)
• assay: ≥99.0% (titration)
• refractive index: n20/D 1.62 (lit.)
• bp: 196 °C (lit.)
• mp: 54-58 °C (lit.)
• solubility: H₂O: 1 g/10 mL
• density: 1.62 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: OC(=O)C(Cl)(Cl)Cl
• InChI: 1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
• InChI key: YNJBWRMUSHSURL-UHFFFAOYSA-N

Descripción

Application

Trichloroacetic acid (TCA) can be used as a catalyst to synthesize:

• β-enaminones via condensation reaction of 1,3-dicarbonyl compounds and amines.
• 6-amino-3-methyl-1,4-diphenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile derivatives via four-component condensation reaction of ethyl acetoacetate, phenylhydrazine, malononitrile, and aromatic aldehydes.
• Tetrahydrobenzo[a]xanthen-11-ones by three-component reaction of aldehydes, 2-naphthol and dimedone.

Tradicionalmente usado para precipitar proteínas. Se ha utilizado para determinar la concentración de proteína por gravimetría. Usado como descalcificador y fijador en microscopía.

Información de seguridad

• pictograms: GHS05,GHS09
• signalword: Danger
• hcodes: H314,H410
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A
• Storage Class: 8B - Non-combustible corrosive hazardous materials
• wgk_germany: WGK 2
• flash_point_f: >235.4 °F - closed cup
• flash_point_c: > 113 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges