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Key Documents

EZRGRA

Millipore

Rat/Mouse Ghrelin ELISA Kit

measures and quantifies active Ghrelin in 20 μL serum or plasma

Sinónimos:

Appetite-regulating hormone

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About This Item

UNSPSC Code:
12161503
eCl@ss:
32161000
NACRES:
NA.32

product name

Rat/Mouse Ghrelin (active) ELISA, This Rat/Mouse Ghrelin (active) ELISA is used to measure & quantify Ghrelin levels in Metabolism & Endocrine research.

Quality Level

species reactivity

rat, mouse

packaging

kit of 1 × 96 wells

parameter

20 μL sample volume (4hr assay)

technique(s)

ELISA: suitable

input

sample type serum
sample type plasma (K2 EDTA)

application(s)

research use

assay range

inter-assay cv: 1-10%
intra-assay cv: 0.3-7%
(Serum)

inter-assay cv: 1-5%
intra-assay cv: 1-6%
(Plasma)

detection method

colorimetric (450nm/590nm)

shipped in

wet ice

storage temp.

2-8°C

General description

Circulating ghrelin is a multifunctional hormone secreted primarily by the stomach. Originally found as an endogenous ligand for the growth hormone secretagogue receptor, it is also an appetite-stimulating hormone in the regulation of energy homeostasis. It consists of 28 amino acids and the n-octanoylation of serine-3 position is necessary for its bioactivity. Long considered a key player in obesity, ghrelin may also play a role in maintaining the balance between insulin and glucose and the development of diabetes. The spike in insulin secretion occurring after eating usually correlates with a dip in ghrelin production. Researchers determined that in rat models of uncontrolled diabetes, food intake still suppressed ghrelin concentrations in the blood, but only approximately half as effectively as when insulin was present.

Millipore is pleased to offer a new Rat/Mouse Ghrelin (Active) ELISA kit for the quantification of active ghrelin in rat and mouse serum or plasma samples. Each kit is sufficient to measure 39 unknown samples in duplicate.

Specificity

Rat/Mouse Ghrelin (Active) - 100%
Rat/Mouse "Des-Octanoyl" Ghrelin - 0%
Canine Ghrelin (Active) - 111%
Porcine Ghrelin (Active) - 98%

Application

Used to detect/quantify: Ghrelin

Other Notes

Please contact Technical Service for linearity of dilution.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects


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Ghrelin ameliorates hypoxia-induced pulmonary hypertension via phospho-GSK3{beta}{beta}-catenin signaling in neonatal rats.
Xu YP, Zhu JJ, Cheng F, Jiang KW, Gu WZ, Shen Z, Wu YD, Liang L, Du LZ
Journal of Molecular Endocrinology null
Sang-Mi Woo et al.
Molecular medicine reports, 17(2), 2665-2672 (2017-12-06)
Chemotherapy frequently causes anorexia in cancer patients, which has been associated with poor disease prognosis. Several therapeutic strategies for the treatment of chemotherapy‑induced anorexia are available; however, their adverse effects limit their clinical use. Herbal medicines have a long history
Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons.
Briggs DI, Enriori PJ, Lemus MB, Cowley MA, Andrews ZB
Endocrinology null

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