R-011
Ritalinic acid hydrochloride solution
1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Fórmula empírica (notación de Hill):
C13H17NO2 · HCl
Número de CAS:
Peso molecular:
255.74
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Productos recomendados
grade
certified reference material
Quality Level
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol (as free base)
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
forensics and toxicology
format
single component solution
storage temp.
−20°C
SMILES string
Cl.OC(=O)C(C1CCCCN1)c2ccccc2
InChI
1S/C13H17NO2.ClH/c15-13(16)12(10-6-2-1-3-7-10)11-8-4-5-9-14-11;/h1-3,6-7,11-12,14H,4-5,8-9H2,(H,15,16);1H
InChI key
SCUMDQFFZZGUQY-UHFFFAOYSA-N
General description
Ritalin®ic acid is a primary blood metabolite of methylphenidate, a psychostimulant sold under trade names Concerta® and Ritalin®. This Certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications for urine drug testing, clinical toxicology, and forensic analysis. Methylphenidate is prescribed for treatment of attention-deficit hyperactivity disorder (ADHD), tachycardia, and narcolepsy.
Application
- Genotoxicity research in non-human primates: Ritalinic acid hydrochloride, a primary metabolite of methylphenidate, is used in genetic toxicology studies to evaluate potential genotoxic effects, aiding in the assessment of safety profiles for neuropharmacological treatments (Morris et al., 2009).
- Pharmacokinetics and mutagenicity studies: Ritalinic acid hydrochloride is used in dose-range and mutagenicity research. It helps in studying the pharmacokinetics and toxicological impact of methylphenidate, offering important insights into its safety and effectiveness in therapeutic applications (Manjanatha et al., 2008).
- Bioequivalence and food effect studies: In clinical pharmacology, ritalinic acid hydrochloride is instrumental in conducting bioequivalence studies of dexmethylphenidate, examining the influence of food on drug absorption and metabolism, crucial for optimizing drug administration protocols (Teo et al., 2004).
- Childhood pharmacotherapy: Research using ritalinic acid hydrochloride explores the effects of methylphenidate when administered with or without food, highlighting its impact on the plasma concentration of the drug and its acid metabolite, informing pediatric dosing guidelines (Chan et al., 1983).
- Hyperkinetic disorders treatment studies: Ritalinic acid hydrochloride supports pharmacokinetic studies in children with hyperkinetic disorders, aiding in understanding how methylphenidate behaves within the body to improve therapeutic strategies (Hungund et al., 1979).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Concerta is a registered trademark of ALZA Corporation
Ritalin is a registered trademark of Novartis Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
related product
Referencia del producto
Descripción
Precios
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
target_organs
Eyes,Central nervous system
Storage Class
3 - Flammable liquids
wgk_germany
WGK 2
flash_point_f
49.5 °F - closed cup
flash_point_c
9.7 °C - closed cup
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Los clientes también vieron
Emilia Marchei et al.
Therapeutic drug monitoring, 32(4), 508-511 (2010-06-11)
The pharmacokinetics of methylphenidate (MPH), a prescription amphetamine derivative used in the treatment of attention-deficit hyperactivity disorder, has been amply described in conventional biological matrices. Recently, the excretion of MPH and its principal metabolite, ritalinic acid (RA) in oral fluid
D R Doerge et al.
Rapid communications in mass spectrometry : RCM, 14(8), 619-623 (2000-04-29)
Methylphenidate (MP, Ritalin) is a psychotropic drug widely prescribed to children for treating the symptoms of attention deficit disorder with and without hyperactivity. Because little information exists about the effects of chronic MP administration on cognitive function in children, measures
Steve K Teo et al.
Journal of clinical pharmacology, 44(2), 173-178 (2004-01-30)
Attention deficit hyperactivity disorder (ADHD) in children is effectively treated by racemic oral methylphenidate (dl-MPH). The d-isomer (d-MPH) has been developed as an improved treatment for ADHD since only half the racemic dose is used. This study, performed in healthy
Mugimane G Manjanatha et al.
Environmental and molecular mutagenesis, 49(8), 585-593 (2008-07-12)
Methylphenidate hydrochloride (MPH) is one of the most frequently prescribed pediatric drugs for the treatment of attention deficit hyperactivity disorder. In a recent study, increased hepatic adenomas were observed in B6C3F1 mice treated with MPH in their diet. To evaluate
Maria del Mar Ramirez Fernandez et al.
Journal of analytical toxicology, 31(8), 497-504 (2007-11-09)
A validated method for the simultaneous analysis of multiple hallucinogens, chlorpheniramine, ketamine, ritalinic acid, and several metabolites is presented. The procedure comprises a sample clean-up step, using mixed-mode solid-phase extraction followed by liquid chromatography (LC)-tandem mass spectrometry analysis. Chromatographic separation
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico