O-005

Oxycodone-D₃ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Fórmula empírica (notación de Hill): C₁₈H₁₈NO₄D₃
• Número de CAS: 160227-46-3
• Peso molecular: 318.38
• EC Number: 200-659-6
• MDL number: MFCD28038719
• UNSPSC Code: 41116107
• PubChem Substance ID: 329818814
• NACRES: NA.24

Propiedades

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)
• concentration: 100 μg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: 2-8°C
• SMILES string: O[C@]1([C@H](N(C)CC2)C3)[C@@]42C5=C3C=CC(OC([2H])([2H])[2H])=C5O[C@H]4C(CC1)=O
• InChI: 1S/C18H21NO4/c1-19-8-7-17-14-10-3-4-12(22-2)15(14)23-16(17)11(20)5-6-18(17,21)13(19)9-10/h3-4,13,16,21H,5-9H2,1-2H3/t13-,16+,17+,18-/m1/s1/i2D3
• InChI key: BRUQQQPBMZOVGD-CLILCLBHSA-N

Descripción

General description

A stable-labeled internal standard suited for quantitation of oxycodone levels in urine, serum, or plasma by LC/MS or GC/MS for urine drug testing, clinical toxicology, forensic analysis, or isotope dilution methods. Oxycodone is a semi-synthetic opioid analgesic sold under many trade names including OxyContin^® and Percocet^® for treatment of moderate to severe pain. Oxycodone is also sold illicitly under street names such as "Roxies," "Blues," and "Perks".

Application

• Pharmacokinetic analysis of oxycodone: A study utilized LC-MS/MS to simultaneously determine acetaminophen and oxycoDonein human plasma, aiding pharmacokinetic research and potentially optimizing therapeutic dosing strategies (Lu et al., 2018).


• Role in bioanalytical assays: Research emphasized the importance of using highly pure internal standards, such as Oxycodone-D₃, in liquid chromatography/tandem mass spectrometric bioanalytical assays, crucial for accurate and reliable analytical results (Bergeron et al., 2009).


• In vivo transport studies: Investigation into the blood-brain barrier transport of oxycoDonein rats suggests active influx mechanisms, offering insights that are critical for understanding oxycodone′s pharmacodynamics and its effects within the central nervous system (Bostrm et al., 2006).


• Postmortem distribution of oxycodone: A study examined the postmortem tissue distribution of oxycodone, which can be informative for forensic toxicology and understanding the drug′s behavior after death, contributing to legal and medical analyses (Anderson et al., 2002).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

OxyContin is a registered trademark of Purdue Pharma L.P.

Percocet is a registered trademark of Endo Pharmaceuticals Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H301 + H311 + H331,H370
• pcodes: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• target_organs: Eyes
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 1
• flash_point_f: 49.5 °F - closed cup
• flash_point_c: 9.7 °C - closed cup