H54409

trans-4-Hydroxy-L-proline

≥99%, for peptide synthesis

• Sinónimos: (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp
• Fórmula empírica (notación de Hill): C₅H₉NO₃
• Número de CAS: 51-35-4
• Peso molecular: 131.13
• Beilstein/REAXYS Number: 81441
• EC Number: 200-091-9
• MDL number: MFCD00064320
• UNSPSC Code: 12352209
• PubChem Substance ID: 24895692
• NACRES: NA.22

Propiedades

• product name: trans-4-Hydroxy-L-proline, ≥99%
• assay: ≥99%
• form: crystalline powder
• optical activity: [α]25/D −75.6°, c = 1 in H₂O
• reaction suitability: reaction type: solution phase peptide synthesis
• color: white to off-white
• mp: 273 °C (dec.) (lit.)
• application(s): peptide synthesis
• SMILES string: O[C@H]1CN[C@@H](C1)C(O)=O
• InChI: 1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
• InChI key: PMMYEEVYMWASQN-DMTCNVIQSA-N

Descripción

General description

Trans-4-hydroxy-L-proline is an isomer of hydroxyproline used as a chiral building block in the production of many pharmaceuticals like neuroexcitatory kainoids.

Application

Versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins. Also employed in the synthesis of chiral ligands for enantioselective ethylation of aldehydes.

Other Notes

Natural constituent of animal structural proteins such as collagen and elastin.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• ppe: Eyeshields, Gloves, type N95 (US)