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707066

Sigma-Aldrich

DCA Deblock (0.36M dichloroacetic acid in toluene)

Sinónimos:

DCA Deblock, DEBLOCK (0.36M dichloroacetic acid in toluene)

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About This Item

Fórmula empírica (notación de Hill):
C2H2Cl2O2
Número de CAS:
79-43-6
Peso molecular:
128.94
MDL number:
MFCD00004223
UNSPSC Code:
12352106
PubChem Substance ID:
329762686

form

liquid

Quality Level

100

concentration

≤100 ppm in H2O

bp

110-111 °C

density

0.884 g/mL at 25 °C

SMILES string

OC(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI key

JXTHNDFMNIQAHM-UHFFFAOYSA-N

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General description

Deblock solution, containing dichloroacetic acid (DCA) in dichloromethane or Toluene, removes the dimethoxytrityl (DMT) protecting the group from the 5′ hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′ hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction.

Application

DCA Deblock (0.36M dichloroacetic acid in toluene) is suitable for the removal of 4,4Adimethoxytrityl (DMTr) protecting groups for the synthesis of antisense oligonucleotides in high yield and purity.

signalword

Danger

Hazard Classifications

Aquatic Chronic 3 - Asp. Tox. 1 - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

41.0 °F

flash_point_c

5 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificados de análisis (COA)

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A H Krotz et al.
Bioorganic & medicinal chemistry, 7(3), 435-439 (1999-04-29)
It is demonstrated that a solution of dichloroacetic acid in toluene removes dimethoxytrityl groups from the 5'-terminus of an antisense phosphorothioate oligodeoxyribonucleotide (ISIS 5132/CGP69846A) during synthesis on solid support cleanly and efficiently. It is therefore suggested to replace health hazardous
Synthesis of an antisense oligonucleotide targeted against C-raf kinase: efficient oligonucleotide synthesis without chlorinated solvents
A H Krotz and D L Cole V T Ravikumar
Bioorganic & Medicinal Chemistry, 7(3), 435-439 (1999)
Haihua Xiao et al.
Chemical communications (Cambridge, England), 48(87), 10730-10732 (2012-09-27)
A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.
Yong Won Choi et al.
Cancer letters, 346(2), 300-308 (2014-02-01)
To investigate sensitization of metformin-cytotoxicity, cancer cells were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK). Metformin-cytotoxicity was mainly dependent on glucose availability and reducing power generated by pentose phosphate pathway, whereas DCA cotreatment enhanced metformin-cytotoxicity via
Toshimitsu Ohashi et al.
International journal of cancer, 133(5), 1107-1118 (2013-02-20)
The activation of oncogenic signaling pathways induces the reprogramming of glucose metabolism in tumor cells and increases lactic acid secretion into the tumor microenvironment. This is a well-known characteristic of tumor cells, termed the Warburg effect, and is a candidate
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