Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Functional understanding of the versatile protein copper metabolism MURR1 domain 1 (COMMD1) in copper homeostasis.

Annals of the New York Academy of Sciences (2014-04-05)

Alina Fedoseienko, Paulina Bartuzi, Bart van de Sluis

ABSTRACT

Copper is an important cofactor in numerous biological processes in all living organisms. However, excessive copper can be extremely toxic, so it is vital that the copper level within a cell is tightly regulated. The damaging effect of copper is seen in several hereditary forms of copper toxicity in humans and animals. At present, Wilson's disease is the best-described and best-studied copper-storage disorder in humans; it is caused by mutations in the ATP7B gene. In dogs, a mutation in the COMMD1 gene has been found to be associated with copper toxicosis. Using a liver-specific Commd1 knockout mouse, the biological role of Commd1 in copper homeostasis has been confirmed. Yet, the exact mechanism by which COMMD1 regulates copper homeostasis is still unknown. Here, we give an overview of the current knowledge and perspectives on the molecular function of COMMD1 in copper homeostasis.

MATERIALS

Product Number

Brand

Product Description

GF68913164

Copper, mesh, 300x300mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF13846877

Copper, rod, 100mm, diameter 16mm, as drawn, 99.99+%

GF59430304

Copper, mesh, 150x150mm, nominal aperture 0.14mm, thickness 0.25mm, wire diameter 0.115mm, 100x100 wires/inch, open area 30.3%, plain weave mesh

GF73997386

Copper, microfoil, disks, 10mm, thinness 0.5μm, specific density 448μg/cm², permanent mylar 3.5μm support, 99.99+%

GF07134960

Copper, insulated wire, 50m, conductor diameter 0.125mm, insulation thickness 0.01mm, polyimide insulation, 99.99%

GF21744952

Copper, insulated wire, 20m, conductor diameter 0.125mm, insulation thickness 0.002mm, 2 micron polyesterimide insulation, 99.9%

GF53876256

Copper, rod, 200mm, diameter 8.0mm, as drawn, 99.99+%

GF00920898

Copper, rod, 100mm, diameter 9.5mm, hard, 99.9%

GF15111458

Copper, rod, 200mm, diameter 9.5mm, hard, 99.9%

GF84488462

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Copper, insulated wire, 50m, conductor diameter 0.1mm, insulation thickness 0.015mm, 10-30 micron polyesterimide insulation, 99.9%

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Copper, rod, 500mm, diameter 2.0mm, as drawn, 99.99+%

GF69447280

Copper, tube, 100mm, outside diameter 0.75mm, inside diameter 0.23mm, wall thickness 0.26mm, as drawn, 99.9%

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Copper, tube, 1000mm, outside diameter 1.0mm, inside diameter 0.24mm, wall thickness 0.38mm, as drawn, 99.9%

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Copper, sphere, 200pcs, diameter 3.0mm, precision sphere grade 200

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Copper, wire reel, 5m, diameter 0.05mm, as drawn, 99.99+%

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GF32292952

Copper - O.F.H.C., rod, 100mm, diameter 25.4mm, as drawn, 99.99+%