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  • Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.

Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.

Archives of toxicology (2002-03-27)
Daan Noort, Albert G Hulst, Rob Jansen
ABSTRACT

Covalent binding of various clinically important nitrogen mustards to the cysteine-34 residue of human serum albumin, in vitro and in vivo, is demonstrated. A rapid method for detection of these adducts is presented, based on liquid chromatography-tandem mass spectrometry analysis of the adducted tripeptide Cys*-Pro-Phe after digestion of the protein with Pronase.

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Sigma-Aldrich
Bis(2-chloroethyl)amine hydrochloride, 98%
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