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  • Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide.

Development of DNA-compatible hydroxycarbonylation reactions using chloroform as a source of carbon monoxide.

Bioorganic & medicinal chemistry (2021-04-12)
Wentao Liu, Wei Huang, Qian Lin, Mei-Hsuan Tsai, Rui Zhang, Lijun Fan, Jack D Scott, Guansai Liu, Jinqiao Wan
ABSTRACT

A robust palladium-catalyzed hydroxycarbonylation of aryl halides on DNA has been developed. Instead of Mo(CO)6 as a source of carbon monoxide as previously described in the literature, chloroform was used as a surrogate in this report for the purpose of avoiding to use a large excess of molybdenum reagent which is not totally soluble in aqueous reaction mixtures.

MATERIALS
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Sigma-Aldrich
sSPhos Pd G2, 95%
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