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  • Design, synthesis, antibacterial, and QSAR studies of myristic acid derivatives.

Design, synthesis, antibacterial, and QSAR studies of myristic acid derivatives.

Bioorganic & medicinal chemistry letters (2006-03-24)
Balasubramanian Narasimhan, Vishnukant Mourya, Avinash Dhake
ABSTRACT

A series of esters and amides of myristic acid was synthesized and tested in vitro for antibacterial activity against gram-positive and gram-negative bacteria. All the compounds showed activity comparable to that of the standard drug, ciprofloxacin. The structural characteristics governing antibacterial activity of myristic acid derivatives was studied using QSAR methodology. The results showed that the antibacterial activity could be modeled using the topological descriptor, valence molecular connectivity index. The predictive ability of the models was cross-validated by construction of a test set. The low residual activity and high cross-validated r2 values (r(cv)2) observed indicated the predictive ability of the developed QSAR models.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Isopropyl myristate, ≥98%
Pricing and availability is not currently available.
Sigma-Aldrich
Methyl myristate, ≥98%, FG
Pricing and availability is not currently available.
Sigma-Aldrich
Myristic acid, natural, ≥98.5%, FG
Pricing and availability is not currently available.
Sigma-Aldrich
Myristic acid, ≥98.0% (GC)
Pricing and availability is not currently available.
Supelco
Methyl myristate, analytical standard
Pricing and availability is not currently available.
Supelco
Myristic acid, analytical standard
Pricing and availability is not currently available.
Sigma-Aldrich
Ethyl myristate, 99% (GC)
Pricing and availability is not currently available.
Sigma-Aldrich
Myristic acid, ≥95%, FCC, FG
Pricing and availability is not currently available.
Sigma-Aldrich
Ethyl myristate, ≥98%, FCC, FG
Pricing and availability is not currently available.
Sigma-Aldrich
Isopropyl myristate, 98%
Pricing and availability is not currently available.
Sigma-Aldrich
Myristic acid, Sigma Grade, ≥99%
Pricing and availability is not currently available.
Sigma-Aldrich
Isopropyl myristate, ≥90% (GC)
Pricing and availability is not currently available.
Sigma-Aldrich
Methyl myristate, ≥99% (GC)
Pricing and availability is not currently available.
Sigma-Aldrich
Ciprofloxacin, ≥98% (HPLC)
Pricing and availability is not currently available.