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Prevention of sevoflurane delirium and agitation with propofol.

Anesthesia progress (2013-06-15)
Zakaria Messieha
ABSTRACT

Emergence delirium and agitation (EAD) associated with sevoflurane general anesthesia are very commonly observed in young children. Such events pose a risk for injury as well as decreased parental satisfaction, especially in the ambulatory and office-based setting. This article reviews the different approaches described in the literature to reduce EAD. A novel approach using a Bispectral Index System (BIS)-guided anesthesia with propofol washout technique is proposed as a viable and effective approach to prevent EAD.

MATERIALS
Product Number
Brand
Product Description

Propofol, European Pharmacopoeia (EP) Reference Standard
Sigma-Aldrich
2,6-Diisopropylphenol, 97%
Propofol for peak identification, European Pharmacopoeia (EP) Reference Standard
Sevoflurane, European Pharmacopoeia (EP) Reference Standard
Supelco
Propofol solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®