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SRP0375

Sigma-Aldrich

LOXL2 human

recombinant, expressed in FreeStyle™ 293-F cells, ≥86% (SDS-PAGE)

Synonym(s):

LOR2, WS9-14, lysyl oxidase-like 2

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human

recombinant

expressed in FreeStyle™ 293-F cells

Assay

≥86% (SDS-PAGE)

form

aqueous solution

mol wt

85 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

0.23 mg/mL

NCBI accession no.

NM_002318

UniProt accession no.

Q9Y4K0

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... LOXL2(4017)

General description

Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.
Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.

Biochem/physiol Actions

Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.

Physical form

Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.

Legal Information

FreeStyle is a trademark of Invitrogen Corp.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Olivier G de Jong et al.
Journal of cellular and molecular medicine, 20(2), 342-350 (2015-11-28)
Exosomes are important mediators of intercellular communication. Additionally, they contain a variety of components capable of interacting with the extracellular matrix (ECM), including integrins, matrix metalloproteinases and members of the immunoglobin superfamily. Despite these observations, research on exosome-ECM interactions is
Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression
Alberto Martin
The Embo Journal, 34(5), 1090-1109 (2015)
Joan Chang et al.
Breast cancer research : BCR, 15(4), R67-R67 (2013-08-27)
Lysyl oxidase-like 2 (LOXL2) is a matrix-remodeling enzyme that has been shown to play a key role in invasion and metastasis of breast carcinoma cells. However, very little is known about its role in normal tissue homeostasis. Here, we investigated
Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma.
Nishikawa R
Febs Letters, 589(16), 2136-2145 (2015)
The function and mechanisms of action of LOXL2 in cancer (Review)
Linghong Wu and Ying Zhu
International Journal of Molecular Medicine, 1200-1204 (2015)
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