05-23-0310

Natriuretic Peptide, C-Type, Human and Porcine

Member of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone, and vascular growth.

• Synonym(s): Natriuretic Peptide, C-Type, Human and Porcine, CNP, GLSKGCFGLKLDRIGSMSGLGC
• Empirical Formula (Hill Notation): C₉₃H₁₅₇N₂₇O₂₈S₃
• CAS Number: 127869-51-6
• Molecular Weight: 2197.60
• MDL number: MFCD00080348
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥96% (HPLC)
• form: lyophilized solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; desiccated
• color: white to off-white
• solubility: 5% acetic acid: 1 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C93H157N27O28S3/c1-12-52(10)76-91(146)104-42-72(127)108-65(44-122)88(143)114-57(26-30-149-11)82(137)118-64(43-121)80(135)103-39-70(125)106-58(31-48(2)3)78(133)101-41-74(129)110-68(92(147)148)47-151-150-46-67(109-73(128)40-100-77(132)54(23-16-18-27-94)111-89(144)66(45-123)119-85(140)59(32-49(4)5)105-69(124)37-96)90(145)116-62(35-53-21-14-13-15-22-53)79(134)102-38-71(126)107-60(33-50(6)7)84(139)112-55(24-17-19-28-95)81(136)115-61(34-51(8)9)86(141)117-63(36-75(130)131)87(142)113-56(83(138)120-76)25-20-29-99-93(97)98/h13-15,21-22,48-52,54-68,76,121-123H,12,16-20,23-47,94-96H2,1-11H3,(H,100,132)(H,101,133)(H,102,134)(H,103,135)(H,104,146)(H,105,124)(H,106,125)(H,107,126)(H,108,127)(H,109,128)(H,110,129)(H,111,144)(H,112,139)(H,113,142)(H,114,143)(H,115,136)(H,116,145)(H,117,141)(H,118,137)(H,119,140)(H,120,138)(H,130,131)(H,147,148)(H4,97,98,99)/t52-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,76-/m0/s1
• InChI key: UHSBKBYWHCBDCJ-DYGWFTAGSA-N

Description

General description

Member of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone and vascular growth. Inhibits adenylate cyclase activity in a concentration-dependent manner. Stimulates particulate guanylate cyclase activity. Shown to exert neuromodulatory effects independent of guanylate cyclase activation or adenylate cyclase inhibition.

Member of the natriuretic peptide family that shares structural homology with ANP and plays a role in the regulation of body fluid homeostasis, vascular tone, and vascular growth. Inhibits adenylate cyclase activity in a concentration-dependent manner. Stimulates particulate guanylate cyclase activity. Shown to exert neuromodulatory effects independently of guanylate cyclase activation or adenylate cyclase inhibition.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Adenylate cyclase, particulate guanylate cyclase

Product does not compete with ATP.

Reversible: no

Packaging

Yes

Warning

Toxicity: Standard Handling (A)

Sequence

H-Gly-Leu-Ser-Lys-Gly-Cys⁶-Phe-Gly-Leu-Lys-Leu-Asp-Arg-Ile-Gly-Ser-Met-Ser-Gly-Leu-Gly-Cys²²-OH (disulfide bond: 6 → 22)]

Physical form

Sold on the basis of peptide content.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

Kelley, T., et al. 1997. Am. J. Respir. Cell. Mol. Biol. 16, 464; Inoue, A., et al. 1996. Biochem. Biophys. Res. Commun. 221, 703; Savoie, P., et al. 1995. FEBS Lett. 370, 6; Trachte, G.J., et al. 1995. Am. J. Physiol. 268, C978; Koller, K.J., et al. 1991. Science252, 120; Sudoh, T., et al. 1990. Biochem. Biophys. Res. Commun. 168, 863.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable