D0947

Dihydrotanshinone I

≥98% (HPLC)

• Synonym(s): Dihydrotanshinone I, (-)-Dihydrotanshinone I, 15,16-Dihydrotanshinone I
• Empirical Formula (Hill Notation): C₁₈H₁₄O₃
• CAS Number: 87205-99-0
• Molecular Weight: 278.30
• MDL number: MFCD28016070
• UNSPSC Code: 12352200
• PubChem Substance ID: 329798655
• NACRES: NA.25

Properties

• biological source: Salvia miltiorrhiza
• Assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: red
• solubility: ethanol: 1 mg/mL, clear, orange to red
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: 2-8°C
• SMILES string: C[C@H]1COC(C2=C3C4=C(C=C2)C(C)=CC=C4)=C1C(C3=O)=O
• InChI: 1S/C18H14O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-7,10H,8H2,1-2H3/t10-/m0/s1
• InChI key: HARGZZNYNSYSGJ-JTQLQIEISA-N

Description

General description

DihydrotanshinoneI (DHTS) is a tanshinone derivative which is a soluble diterpene quinone pigment of danshen.

Application

Dihydrotanshinone I (DHTS) has been used:

• to study its cytocidal effects on chemosensitive ovarian cancer cells with or without platinum-based chemotherapy
• as a treatment to study its inhibitory effects on triple-negative breast cancer cells growth by modulating epithelial-mesenchymal transition (EMT) markers
• as a potential SARS-CoV-2 papain-like protease (PL^pro) inhibitor
• as a human antigen R (HuR) inhibitor to study its role in Th17 cell differentiation related to autoimmune neuroinflammation
• as a reference standard to analyze Salvia miltiorrhiza Bunge extract (SME) components using high-performance liquid chromatography(HPLC)

Biochem/physiol Actions

Dihydrotanshinone Iis a potent anti-cancer agent with its cytotoxic, apoptosis, cell cycle arresteffects and inhibition of angiogenesis, and metastasis in cancer cells. Italso exerts cardiovascular and cerebrovascular protective effects. DHTS isan anti-inflammatory, anti-ischemia-reperfusion (I/R), anti-allergic,anti-Alzheimer’s disease properties. It is also effective againstdrug-resistant cancer cells.

Tanshinone extracted from a herb, Salvia miltiorrhiza, commonly used in Chinese traditional medicine. A significant decrease in tumor growth was observed using dihydrotanshinone I and irradiation treatment with mouse xenograft model.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable