Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease.

Journal of inorganic biochemistry (2011-11-22)

Maire E Percy, Theo P A Kruck, Aileen I Pogue, Walter J Lukiw

PMID22099160

ABSTRACT

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD.

MATERIALS

Product Number

Brand

Product Description

266957

Sigma-Aldrich

Aluminum, foil, thickness 1.0 mm, 99.999% trace metals basis

326852

Sigma-Aldrich

Aluminum, foil, thickness 0.25 mm, 99.999% trace metals basis

326860

Sigma-Aldrich

Aluminum, foil, thickness 0.13 mm, ≥99.99% trace metals basis

266574

Sigma-Aldrich

Aluminum, foil, thickness 0.45-0.55 mm, 99.999% trace metals basis

338788

Sigma-Aldrich

Aluminum, pellets, 3-12 mm, 99.99% trace metals basis

IRMM523A

Aluminum, IRMM^®, certified reference material, 0.1 mm foil

GF38294646

Aluminum, mesh, 300x300mm, nominal aperture 0.38mm, wire diameter 0.25mm, 40x40 wires/inch, open area 37%, plain weave mesh

GF45982716

Aluminum, insulated wire, 10m, conductor diameter 0.1mm, insulation thickness 0.005mm, polyimide insulation, 99.95+%

GF21371082

Aluminum, wire reel, 100m, diameter 0.7mm, as drawn, 99.5%

GF49592076

Aluminum, wire reel, 100m, diameter 1.0mm, as drawn, 99.999%

GF21518850

Aluminum, wire reel, 1000m, diameter 0.25mm, as drawn, 99.5%

GF52964006

Aluminum, tube, 100mm, outside diameter 1.96mm, inside diameter 1.4mm, wall thickness 0.28mm, as drawn, 99.5%

GF90679191

Aluminum, rod, 1000mm, diameter 12.0mm, as drawn, 99.999%

GF09240858

Aluminum, wire reel, 100m, diameter 1.0mm, as drawn, 99.95+%

GF20899604

Aluminum, rod, 200mm, diameter 6.0mm, as drawn, 99.999%

GF27325942

Aluminum, wire reel, 0.5m, diameter 2.0mm, as drawn, 99.999%

GF04746472

Aluminum, tube, 100mm, outside diameter 1.42mm, inside diameter 1.166mm, wall thickness 0.127mm, as drawn, 99.5%

GF38637850

Aluminum, tube, 100mm, outside diameter 3.0mm, inside diameter 1.62mm, wall thickness 0.69mm, hard, 99.5%

GF25360354

Aluminum, rod, 50mm, diameter 30.0mm, as drawn, 99.999%

GF35425009

Aluminum, tube, 100mm, outside diameter 0.30mm, inside diameter 0.2mm, wall thickness 0.05mm, as drawn, 99.5%

GF74626342

Aluminum, rod, 500mm, diameter 10.0mm, as drawn, 99.999%

GF24582900

Aluminum, wire reel, 0.2m, diameter 3.0mm, as drawn, 99.999%

GF97088068

Aluminum, rod, 500mm, diameter 12.0mm, as drawn, 99.999%

GF14472266

Aluminum, rod, 50mm, diameter 25.0mm, as drawn, 99.999%

GF80418269

Aluminum, tube, 500mm, outside diameter 0.6mm, inside diameter 0.3mm, wall thickness 0.15mm, as drawn, 99.5%

GF80901637

Aluminum, tube, 200mm, outside diameter 0.55mm, inside diameter 0.4mm, wall thickness 0.075mm, as drawn, 99.5%

GF52283404

Aluminum, tube, 1000mm, outside diameter 0.6mm, inside diameter 0.3mm, wall thickness 0.15mm, as drawn, 99.5%

GF87115271

Aluminum, wire reel, 100m, diameter 0.125mm, as drawn, 99.5%

GF58886803

Aluminum, wire reel, 100m, diameter 0.30mm, as drawn, 99.5%

GF76115505

Aluminum, tube, 500mm, outside diameter 0.86mm, inside diameter 0.76mm, wall thickness 0.05mm, as drawn, 99.5%