270873

2-Hydroxyquinoline

98%

• Synonym(s): 2-Quinolinol, Carbostyril
• Empirical Formula (Hill Notation): C₉H₇NO
• CAS Number: 59-31-4
• Molecular Weight: 145.16
• EC Number: 200-420-6
• MDL number: MFCD00006743
• UNSPSC Code: 12352100
• PubChem Substance ID: 24856409
• NACRES: NA.22

Properties

• Assay: 98%
• form: crystals
• mp: 198-199 °C (lit.)
• solubility: alcohol: soluble(lit.); diethyl ether: soluble(lit.); dilute HCl: soluble(lit.); water: slightly soluble (1 g/950mL)(lit.)
• SMILES string: Oc1ccc2ccccc2n1
• InChI: 1S/C9H7NO/c11-9-6-5-7-3-1-2-4-8(7)10-9/h1-6H,(H,10,11)
• InChI key: LISFMEBWQUVKPJ-UHFFFAOYSA-N

Description

General description

2-Hydroxyquinoline is a specific inhibitor of plaque paraoxonase1 (PON1).

Application

2-Hydroxyquinoline was used to obtain the design of the platinum(IV) complexes with intense bands shifted towards longer wavelengths. The Pt(IV) complexes are inert stable prodrugs that were photoactivated to produce Pt(II) species with promising anticancer activity.

Safety Information

• Pictograms: GHS05,GHS07
• Signal Word: Danger
• Hazard Statements: H302,H315,H318,H335
• Precautionary Statements: P261 - P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves