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L0420000

Levodropropizine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

(2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol

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About This Item

Empirical Formula (Hill Notation):
C13H20N2O2
CAS Number:
99291-25-5
Molecular Weight:
236.31
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

levodropropizine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1

InChI key

PTVWPYVOOKLBCG-ZDUSSCGKSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Levodropropizine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Kyung Hee Park et al.
Yonsei medical journal, 54(1), 262-264 (2012-12-12)
We experienced a case of immunoglobulin E (IgE) mediated anaphylaxis to levodropropizine. The patient was an 18-year old Korean woman. After taking the common cold medication including acetaminophen, domperidone, and levodropropizine, skin rash, angioedema and anaphylaxis were developed immediately. As
Yunbiao Tang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 819(1), 185-189 (2005-03-31)
A rapid and sensitive LC-MS-MS method for quantifying levodropropizine in human plasma after oral administration of a single-dose (60 mg/day) was developed and validated. The sample preparation used liquid-liquid extraction with a mixture of dichloromethane-diethyl ether (2:3, v/v) in a
Lin Yan et al.
Archives of pharmacal research, 29(6), 514-519 (2006-07-13)
A simple HPLC method using UV detection was developed and validated for the determination of levodropropizine (LDP) in dog plasma. The sample was prepared for injection using a liquid-liquid extraction method with 1-phenypiperazine as the internal standard. The mobile phase
An anaphylactic reaction caused by levodropropizine.
G-Y Hur et al.
Allergy, 65(3), 409-410 (2009-10-03)
R Bossi et al.
Clinical trials and meta-analysis, 29(1), 9-20 (1994-03-09)
The antitussive compound Levodropropizine (LD) is active in animal bronchoconstriction induced by histamine and capsaicin and in man protects from bronchoconstriction induced by capsaicin. The primary objective of this study was to evaluate the mechanism of action of LD given
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