Skip to Content
Merck
All Photos(3)

Documents

595675

Sigma-Aldrich

2-Bromo-5-fluoropyridine

97%

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C5H3BrFN
CAS Number:
41404-58-4
Molecular Weight:
175.99
MDL number:
MFCD00234011
UNSPSC Code:
12352100
PubChem Substance ID:
24881597
NACRES:
NA.22

Assay

97%

bp

80-83 °C/44 mmHg (lit.)

mp

30-31 °C (lit.)

SMILES string

Fc1ccc(Br)nc1

InChI

1S/C5H3BrFN/c6-5-2-1-4(7)3-8-5/h1-3H

InChI key

UODINHBLNPPDPD-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

2-Bromo-5-fluoropyridine can be used in the synthesis of the following:
  • 5-fluoro-2-phenylpyridine via Suzuki coupling reaction with phenylboronic acid
  • 5-fluoro-2-(p-tolyl)pyridine via Suzuki coupling reaction with p-tolylboronic acid
It can undergo palladium-catalyzed homo-coupling reaction to give the corresponding biaryl. It can also be employed in a palladium-catayzed α-arylation of esters leading to 4-pyridylcarboxypiperidines.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302,H315,H319,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

163.4 °F - closed cup

Flash Point(C)

73 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

"A fast and oxygen-promoted protocol for the ligand-free Suzuki reaction of 2-halogenated pyridines in aqueous media"
Liu C and Yang W
Chemical Communications (Cambridge, England), 41, 6267-6269 (2009)
Lee K and Lee HP
Tetrahedron Letters, 49(27), 4302-4305 (2008)
"A General and Highly Efficient Method for the Construction of Aryl-Substituted N-Heteroarenes"
Liu C, et al.
European Journal of Organic Chemistry, 1010(29), 5548-5551 (2010)
Tetrahedron Letters, 48, 1191-1191 (2007)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service