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Key Documents

337005

Sigma-Aldrich

1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane

97%

Synonym(s):

TIPDSiCl2

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About This Item

Linear Formula:
[(CH3)2CH]2Si(Cl)OSi(Cl)[CH(CH3)2]2
CAS Number:
Molecular Weight:
315.43
Beilstein:
1934216
MDL number:
UNSPSC Code:
12352001
PubChem Substance ID:
NACRES:
NA.22

Assay

97%

form

liquid

refractive index

n20/D 1.454 (lit.)

bp

70 °C/0.5 mmHg (lit.)

density

0.986 g/mL at 25 °C (lit.)

SMILES string

CC(C)[Si](Cl)(O[Si](Cl)(C(C)C)C(C)C)C(C)C

InChI

1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3

InChI key

DDYAZDRFUVZBMM-UHFFFAOYSA-N

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Pictograms

Corrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

168.8 °F

Flash Point(C)

76 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The Journal of Organic Chemistry, 58, 2552-2552 (1993)
W T Markiewicz et al.
Nucleic acids symposium series, (7)(7), 115-127 (1980-01-01)
Recent results concerning the synthesis of oligoribonucleotides via the phosphotriester method, such as functionalization of ribonucleosides, new phosphorylating agents, 5'-O-sulfonylation and chromatography on Sephadex LH-20 for monitoring the removal of internucleotide phosphotriester groups, are presented. To show that efficiency of
Aldrichimica Acta, 15, 11-11 (1982)
M Kwiatkowski et al.
Nucleic acids research, 24(23), 4632-4638 (1996-12-01)
The synthesis of oligodeoxynucleotides is marred by several problems that contribute to the formation of defective molecules. This in turn seriously limits the usefulness of such reagents in DNA diagnostics, molecular cloning, DNA structural analysis and in antisense therapy. In
Suetying Chow et al.
Nucleosides, nucleotides & nucleic acids, 22(5-8), 583-587 (2003-10-21)
An improved strategy for the synthesis of 2'-O-methyl-guanosine (6) and 2'-MOE-guanosine (8) is reported. The regioselectivity of the alkylation was attained using a novel silicon-based protecting group, methylene-bis (diisopropyl-silylchloride) (MDPSCl2, 2). The alkylation proceeded in a chemoselective manner using NaHMDS

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