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Astec® Cellulose DMP Chiral (5 μm) HPLC Column

L × I.D. 25 cm × 4.6 mm, HPLC Column

Synonym(s):

Cellulose DMP Chiral Stationary Phase

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About This Item

UNSPSC Code:
41115700
eCl@ss:
32110501
NACRES:
SB.52

product name

Astec® Cellulose DMP Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm

material

stainless steel column

Agency

suitable for USP L40

product line

Astec®

packaging

pkg of 1 ea

manufacturer/tradename

Astec®

parameter

0-40 °C temperature
50 bar pressure (725 psi)

technique(s)

HPLC: suitable

L × I.D.

25 cm × 4.6 mm

matrix

fully porous particle
silica gel high purity, spherical
silica gel particle platform

matrix active group

cellulose, DMPC- phase

particle size

5 μm

pore size

100 Å pore size

operating pH

3.5-6.8

separation technique

chiral

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General description

Astec® Cellulose DMP HPLC columns separate a wide range of chiral compounds under normal phase, polar organic, and SFC conditions. They exhibit high efficiency, high loading capacity, and excellent column lifetime. With performance comparable to other DMPC-derivatized cellulose CSPs, but at substantially lower price, Astec® Cellulose DMP is a must-have for every chiral column HPLC or SFC screening protocol. Astec® Cellulose DMP is complementary to the other Astec® CSPs, including CHIROBIOTIC®, CYCLOBOND and the P-CAP™ product lines.

Description: Spherical, porous silica coated with DMPC (dimethylphenyl carbamate)-derivatized cellulose
Particle diameter: 5 μm
Field of Use: Small molecule enantiomer separations in normal phase, polar organic, and SFC modes

Application


  • Enantioseparation of Synthetic Cathinones Enantiomers with Tertiary Amine Structure in Urine and Plasma.: This research investigates the application of the Astec Cellulose DMP Chiral HPLC Column for the enantioseparation of synthetic cathinones enantiomers in biological samples. The study demonstrates the column′s efficacy in separating enantiomers with high resolution and sensitivity, particularly in complex matrices such as urine and plasma. This highlights the column′s utility in forensic and clinical analysis, providing a robust method for the detection and quantification of chiral drugs in biological samples (Meetani et al., 2019).

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Legal Information

Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
P-CAP is a trademark of Sigma-Aldrich Co. LLC

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Certificates of Analysis (COA)

Lot/Batch Number
289805-01
289795-01
289794-01
289792-01
288277-01

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Katrijn De Klerck et al.
Journal of pharmaceutical and biomedical analysis, 69, 77-92 (2012-03-01)
Chirality has a significant impact on drug discovery and development processes in the pharmaceutical industry. As the number of enantiopure drugs launched onto the market is yearly increasing, the need for fast and performant enantioseparation methods with minimal costs is
Katrijn De Klerck et al.
Journal of chromatography. A, 1328, 85-97 (2014-01-21)
Since their introduction on the market the applicability of immobilized polysaccharide-based chiral stationary phases in high-performance liquid chromatography has been thoroughly investigated. These immobilized phases have the benefit to be applicable with a wide range of modifiers, potentially extending the

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