SAB1411438
Anti-RPAP3 antibody produced in rabbit
purified immunoglobulin, buffered aqueous solution
Synonym(s):
FLJ21908, spag
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 71.9 kDa
species reactivity
human
technique(s)
western blot: 1 μg/mL
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RPAP3(79657)
General description
RNA polymerase II associated protein 3 (RPAP3) gene encodes an RNA polymerase II-associated protein. The encoded protein may function in transcriptional regulation and may also regulate apoptosis. Alternatively spliced transcript variants have been described. (provided by RefSeq). The protein consists of tetratricopeptide repeat (TPR) domain.
Immunogen
RPAP3 (AAH56415.1, 1 a.a. ~ 631 a.a) full-length human protein.
Sequence
MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATTVLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHDFYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELKKRYGG
Sequence
MTSANKAIELQLQVKQNAEELQDFMRDLENWEKDIKQKDMELRRQNGVPEENLPPIRNGNFRKKKKGKAKESSKKTREENTKNRIKSYDYEAWAKLDVDRILDELDKDDSTHESLSQESESEEDGIHVDSQKALVLKEKGNKYFKQGKYDEAIDCYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAVALNRSYTKAYSRRGAARFALQKLEEAKKDYERVLELEPNNFEATNELRKISQALASKENSYPKEADIVIKSTEGERKQIEAQQNKQQAISEKDRGNGFFKEGKYERAIECYTRGIAADGANALLPANRAMAYLKIQKYEEAEKDCTQAILLDGSYSKAFARRGTARTFLGKLNEAKQDFETVLLLEPGNKQAVTELSKIKKKPLKKVIIEETGNLIQTIDVPDSTTAAAPENNPINLANVIAATGTTSKKNSSQDDLFPTSDTPRAKVLKIEEVSDTSSLQPQASLKQDVCQSYSEKMPIEIEQKPAQFATTVLPPIPANSFQLESDFRQLKSSPDMLYQYLKQIEPSLYPKLFQKNLDPDVFNQIVKILHDFYIEKEKPLLIFEILQRLSELKRFDMAVMFMSETEKKIARALFNHIDKSGLKDSSVEELKKRYGG
Application
Anti-RPAP3 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
RNA polymerase II associated protein 3 (RPAP3) acts as a cell death enhancer. The protein may modulate nuclear factor-kappa B (NF-κb) pathway in apoptosis, which is induced by anti-cancer chemotherapeutic agents. It functions as a Monad binding protein. This protein regulates apoptosis and small nucleolar ribonucleoparticule assembly process.
Physical form
Solution in phosphate buffered saline, pH 7.4
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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1 H, 15 N and 13 C resonance assignments of the two TPR domains from the human RPAP3 protein
Chagot M, et al.
Biomolecular NMR Assignments, 9(1), 99-102 (2015)
RPAP3 enhances cytotoxicity of doxorubicin by impairing NF-kappa B pathway
Shimada K, et al.
Biochemical and Biophysical Research Communications, 404(4), 910-914 (2011)
Molecular cloning of novel Monad binding protein containing tetratricopeptide repeat domains
Itsuki Y, et al.
Febs Letters, 582(16), 2365-2370 (2008)
RPAP3 interacts with Reptin to regulate UV-induced phosphorylation of H2AX and DNA damage
Ni L, et al.
Journal of Cellular Biochemistry, 106(5), 920-928 (2009)
RPAP3 splicing variant isoform 1 interacts with PIH1D1 to compose R2TP complex for cell survival
Yoshida M, et al.
Biochemical and Biophysical Research Communications, 430(1), 320-324 (2013)
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