Skip to Content
Merck
All Photos(1)

Documents

R0658

Sigma-Aldrich

RN-1734

≥98% (HPLC)

Synonym(s):

2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C14H22Cl2N2O2S
CAS Number:
946387-07-1
Molecular Weight:
353.31
MDL number:
MFCD00129453
UNSPSC Code:
12352200
PubChem Substance ID:
329823990
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

2-8°C

SMILES string

ClC1=C(S(N(C(C)C)CCNC(C)C)(=O)=O)C=CC(Cl)=C1

InChI

1S/C14H22Cl2N2O2S/c1-10(2)17-7-8-18(11(3)4)21(19,20)14-6-5-12(15)9-13(14)16/h5-6,9-11,17H,7-8H2,1-4H3

InChI key

IHYZMEAZAIFMTN-UHFFFAOYSA-N

Application

RN-1734 has been used as a transient receptor potential vanilloid 4 (TRPV4) blocker to study its effects on differentiation of a corneal epithelial cell model, RCE1(5T5) cells.

Biochem/physiol Actions

RN-1734 is a selective TRPV4 antagonist.

Storage Class Code

11 - Combustible Solids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

TRPV4 regulates tight junctions and affects differentiation in a cell culture model of the corneal epithelium
Martinez R, et al.
Journal of Cellular Physiology, 232(7), 1794-1807 (2017)
Jacqueline Martínez-Rendón et al.
Journal of cellular physiology, 232(7), 1794-1807 (2016-11-22)
TRPV4 (transient receptor potential vanilloid 4) is a cation channel activated by hypotonicity, moderate heat, or shear stress. We describe the expression of TRPV4 during the differentiation of a corneal epithelial cell model, RCE1(5T5) cells. TRPV4 is a late differentiation
Vittorio Abbonante et al.
Haematologica, 102(7), 1150-1160 (2017-04-16)
Megakaryocytes (MK) in the bone marrow (BM) are immersed in a network of extracellular matrix components that regulates platelet release into the circulation. Combining biological and bioengineering approaches, we found that the activation of transient receptor potential cation channel subfamily
Silvia Ghirga et al.
Journal of the Optical Society of America. A, Optics, image science, and vision, 37(4), 643-652 (2020-05-14)
It has been recently demonstrated that the exposure of naive neuronal cells to light-at the basis of optogenetic techniques and calcium imaging measurements-may alter neuronal firing. Indeed, understanding the effect of light on nongenetically modified neurons is crucial for a
Hemant Kumar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(9), 1943-1955 (2020-01-25)
Currently, the role of transient receptor potential vanilloid type 4 (TRPV4), a nonselective cation channel in the pathology of spinal cord injury (SCI), is not recognized. Herein, we report the expression and contribution of TRPV4 in the pathology of scarring
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service