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D1387

Sigma-Aldrich

P1,P3-Di(adenosine-5′) triphosphate ammonium salt

Synonym(s):

A(5′)P3(5′)A, Diadenosine triphosphate

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About This Item

Linear Formula:
C20H24N9O16P3 · NH3
CAS Number:
102783-40-4
Molecular Weight:
756.41
MDL number:
MFCD00058130
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
24893423
NACRES:
NA.51

form

solid

Quality Level

200

impurities

Other adenosine phosphates, essentially free

storage temp.

−20°C

SMILES string

N.Nc1ncnc2n(cnc12)C3OC(COP(O)(=O)OP(O)(=O)OP(O)(=O)OCC4OC(C(O)C4O)n5cnc6c(N)ncnc56)C(O)C3O

InChI

1S/C20H27N10O16P3.H3N/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(43-19)1-41-47(35,36)45-49(39,40)46-48(37,38)42-2-8-12(32)14(34)20(44-8)30-6-28-10-16(22)24-4-26-18(10)30;/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H2,21,23,25)(H2,22,24,26);1H3

InChI key

PKSQTRWRSNNYCW-UHFFFAOYSA-N

Related Categories

Application

P1,P3-Di(adenosine-5′) triphosphate (Ap3A) is a diadenosine oligophosphate (ApnA) family member. ApnAs have been found to act as a signaling molecule.
P1,P3-Di(adenosine-5′) triphosphate ammonium salt has been used as a component of the incubation medium for incubating fibroblast cell lines for FoF1 ATP-synthase activity.

Quantity

Approx. 25 A260 units per mg.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000284405
0000284405
113F7275
101K7019
079H5956

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Manuela Campiglio et al.
Journal of cellular physiology, 208(2), 274-281 (2006-03-21)
FHIT is a tumor suppressor gene that is frequently inactivated in human cancer. Although the Fhit protein is known to hydrolyze diadenosine triphosphate (Ap(3)A), this hydrolase activity is not required for Fhit-mediated oncosuppression. Indeed, the molecular mechanisms and the regulatory
Dual roles of diadenosine polyphosphates in corneal epithelial cell migration
Mediero A, Peral A, Pintor J.
Investigative Ophthalmology & Visual Science, 47, 4500-4506 (2010)
Michael Wright et al.
The FEBS journal, 273(15), 3534-3544 (2006-08-04)
Heat shock inducible lysyl-tRNA synthetase of Escherichia coli (LysU) is known to be a highly efficient diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) synthase. However, we use an ion-exchange HPLC technique to demonstrate that active LysU mixtures actually have a dual catalytic activity, initially
A S Mildvan et al.
Archives of biochemistry and biophysics, 433(1), 129-143 (2004-12-08)
Nudix hydrolases catalyze the hydrolysis of nucleoside diphosphates linked to other moieties, X, and contain the sequence motif or Nudix box, GX(5)EX(7)REUXEEXGU. The mechanisms of Nudix hydrolases are highly diverse in the position on the substrate at which nucleophilic substitution
Filip Golebiowski et al.
Archives of biochemistry and biophysics, 428(2), 160-164 (2004-07-13)
Fhit protein is the product of the putative tumor suppressor fragile histidine triad (FHIT) gene. The way by which Fhit exerts its antitumor activity remains largely unknown, although the Fhit-Ap3A complex is believed to be the native signaling form of
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