FastWoRX for Faster and Greener Alternative to Liquid-Liquid Extraction

Many organic chemists routinely do reaction “work-up” with liquid-liquid extraction (LLE) to clean up after their reactions. After a reaction is quenched, an aqueous mixture containing organic products, inorganic byproducts and solvent is generated and LLE is commonly used to extract the organic products. The labor- and solvent-intensive nature of liquid-liquid extraction and its hazardous conditions have not changed fundamentally for 150 years. We have developed a substantially faster and greener technique for routine chemical reactions work-ups. Our innovative and unique patent-pending hydrophobic FastWoRX^™ powders¹, FastWoRX-S and FastWoRX-M, are used as an absorbent to extract organic products from a quenched aqueous reaction mixture. FastWoRX-S is our standard powder and FastWoRX-M is a magnetic powder. After filtration, the FastWoRX powder loaded with organic products can serve as a convenient input for flash chromatographic separation or other processing. With this technique, tedious and solvent-consuming liquid-liquid extractions are replaced by a simple filtration. Millipore Sigma is proud to offer this novel work-up product – FastWoRX - in collaboration with Faster Chemistry LLC.

Advantages over Traditional Liquid-Liquid Extraction Work-Up²

• Work-ups in half the time or less
• 90% less solvent use
• No emulsions
• Easy automation
• Easy parallelization
• Simple solid separation replaces LLE
• Scalable - milligrams to kilograms

Advantages over Traditional Liquid-Liquid Extraction Work-Up²

No sep funnels or liquid-liquid extraction!

Greatly reduce solvent use and disposal!

No emulsions!

References

1. Shi, Z.; Hammond, G. B.; Xu, B., Faster and Greener Chemical Reaction Workup Using Silicone Elastomer-Coated Glass Powders. ACS Omega 2018, 3 (6), 6748-6756.. [Internet]. Available from: https://pubs.acs.org/doi/10.1021/acsomega.8b00966

2. More information. [Internet]. Available from: https://fasterchemistry.com