- LC-MS of novel narcoepileptics and related substances.
LC-MS of novel narcoepileptics and related substances.
Journal of separation science (2009-04-29)
Ramisetti Nageswara Rao, Dhananjay D Shinde, Venna Ramesh, Ragampeta Srinivas
PMID19399862
RÉSUMÉ
Modafinil, adrafinil and their related substances were synthesized and analyzed by RP-LC with ESI-MS/MS. The ionization mode, polarity, cone voltage, and chromatographic conditions were evaluated. The optimum LC-MS conditions to obtain fragment ions indispensable for identification of the structures were described. The bulk drugs purity of modafinil and adrafinil was evaluated on Kromasil C(18) column with ACN/0.02 M ammonium acetate as mobile phase in gradient elution mode at 30 degrees C. The method was found to be suitable not only for monitoring the reactions during the process development but also for quality assurance of modafinil and adrafinil.
MATÉRIAUX
Référence du produit
Marque
Description du produit
Supelco
Précolonne Discovery® C18 Supelguard, 5 μm particle size, L × I.D. 2 cm × 4 mm, pkg of 2 ea
Supelco
Précolonne Discovery® C18 Supelguard, 5 μm particle size, L × I.D. 2 cm × 2.1 mm, pkg of 2 ea
Supelco
Précolonne Discovery® C18 Supelguard, 5 μm particle size, L × I.D. 2 cm × 3 mm, pkg of 2 ea