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Chain-like assembly of gold nanoparticles on artificial DNA templates via 'click chemistry'.

Chemical communications (Cambridge, England) (2007-12-20)
Monika Fischler, Alla Sologubenko, Joachim Mayer, Guido Clever, Glenn Burley, Johannes Gierlich, Thomas Carell, Ulrich Simon
PMID18092076
RÉSUMÉ

We present a new type of azide-functionalized gold nanoparticle and their coupling to an alkyne-modified DNA duplex using the copper(I)-catalyzed Huisgen cycloaddition ('click chemistry'), resulting in a chain-like assembly of nanoparticles on the DNA template.

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