16024AST
Astec® CHIROBIOTIC® T2 Chiral (5 μm) HPLC Columns
L × I.D. 25 cm × 4.6 mm, HPLC Column
Synonyme(s) :
T2 Chiral Stationary Phase Column
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About This Item
Code UNSPSC :
41115700
eCl@ss :
32110501
Nomenclature NACRES :
SB.52
Produits recommandés
product name
Astec® Chirobiotic® T2 Chiral HPLC Column, 5 μm particle size, L × I.D. 25 cm × 4.6 mm
Matériaux
stainless steel column
Niveau de qualité
Agence
suitable for USP L63
Description
HPLC column
Gamme de produits
Astec®
Conditionnement
pkg of 1 ea
Fabricant/nom de marque
Astec®
Paramètres
0-45 °C temperature
241 bar pressure (3500 psi)
Technique(s)
HPLC: suitable
LC/MS: suitable
L × D.I.
25 cm × 4.6 mm
Matrice
high-purity silica gel particle platform
fully porous particle
Taille des particules
5 μm
Dimension de pores
200 Å
operating pH range
3.8-6.8
Technique de séparation
chiral
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Description générale
CHIROBIOTIC® T and T2 have teicoplanin as the chiral selector. They offer unique selectivity for a number of classes of molecules, specifically underivatized α, β, γ and cyclic amino acids, N-derivatized amino acids, hydroxy-carboxylic acids, acidic compounds including carboxylic acids and phenols, small peptides, neutral aromatic analytes and cyclic aromatic and aliphatic amines. Separations normally obtained on a chiral crown ether or ligand exchange-type CSPs are also possible on the CHIROBIOTIC® T and T2, but in much simpler mobile phases, like water-alcohol. In addition, all of the known beta-blockers (amino alcohols), and dihydrocoumarins have been resolved. CHIROBIOTIC® T and T2 differ in their bonding chemistry and the pore size of the support particle, giving them different selectivity and preparative capacity.
- Bonded phase: Teicoplanin
- Operating pH range: 3.8 - 6.8
- Particle diameter: 5, 10 or 16 μm
- Pore size: 100 Å (CHIROBIOTIC® T) or 200 Å (CHIROBIOTIC® T2)
Application
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This research employs the Astec® CHIROBIOTIC T2 Chiral HPLC Column for the enantioseparation of various amino acids. The study highlights the column′s effectiveness in separating complex chiral molecules, demonstrating its application in the analysis of amino acids and related compounds in chemical and pharmaceutical research (Berkecz et al., 2009).
Informations légales
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Code de la classe de stockage
13 - Non Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
David H Mast et al.
ACS chemical biology, 15(1), 272-281 (2019-12-27)
d-Amino acid-containing peptides (DAACPs) make up a class of post-translationally modified peptides in animals that play important roles as cell-to-cell signaling molecules. Despite the functional importance of l- to d-residue isomerization, little is known about its prevalence, mostly due to
Chromatographic Separations and Analysis: Macrocyclic Glycopeptide Chiral Stationary Phases
Berthod, A.
Comprehensive Chirality, 8, 227-262 (2012)
Ping Sun et al.
Journal of molecular structure, 890(1-3), 75-80 (2008-11-12)
A high performance liquid chromatographic method using macrocyclic glycopeptide chiral stationary phases (CSPs) was used to separate enantiomers of seven ruthenium(II) polypyridyl complexes. Among the five different CSPs, the Chirobiotic T2 was most effective and baseline separated all complexes. All
Chris Hamman et al.
Journal of chromatography. A, 1305, 310-319 (2013-07-31)
A rapid screening method to identify the best conditions for chiral separations is described. We analyzed a representative set of 80 racemic compounds against 25 different chiral stationary phases with three different mobile phases to identify the combination of columns
Chromatograms
application for HPLCapplication for HPLCapplication for HPLCapplication for HPLCAfficher plusNotre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..
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