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V1255

Sigma-Aldrich

D-Valine

BioReagent, suitable for cell culture

Synonyme(s) :

(R)-α-Aminoisovaleric acid, D-2-Amino-3-methylbutanoic acid

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About This Item

Formule linéaire :
(CH3)2CHCH(NH2)CO2H
Numéro CAS:
640-68-6
Poids moléculaire :
117.15
Numéro Beilstein :
1721135
Numéro CE :
211-368-9
Numéro MDL:
MFCD00064219
Code UNSPSC :
12352209
ID de substance PubChem :
24900713
Nomenclature NACRES :
NA.75

Source biologique

synthetic (organic)

Niveau de qualité

200

Gamme de produits

BioReagent

Forme

powder

Technique(s)

cell culture | mammalian: suitable

Pf

>295 °C (subl.) (lit.)

Conditions d'expédition

ambient

Température de stockage

room temp

Chaîne SMILES 

CC(C)[C@@H](N)C(O)=O

InChI

1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m1/s1

Clé InChI

KZSNJWFQEVHDMF-SCSAIBSYSA-N

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Description générale

L-Valine is an essential non-polar amino acid. D-Valine is the non-proteinogenic isomer of valine.

Application

D-Valine has been used as a supplement in:
  • Dulbecco′s modified Eagle′s medium (DMEM)/Nutrient Mixture F-12 Ham (F-12) for mice renal proximal tubule cell (RPTC) culture
  • endothelial cell growth medium MV2 for rat lung microvascular endothelial cell (RLMEC) culture
  • DMEM/F-12 for mouse tracheal epithelial cell (MTEC) culture

Actions biochimiques/physiologiques

D-Valine has a broad range of industrial applications such as semi-synthetic veterinary antibiotics, pharmaceutical drugs, and agricultural pesticides.
D-valine is used in cell culture as a selective inhibitor of cell proliferation, wherein it inhibits cells that lack the enzyme D-amino acid oxidase. Historically D-valine has been used to inhibit fibroblast growth while allowing selective growth of epithelial cells.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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S F Gilbert et al.
Cell, 5(1), 11-17 (1975-05-01)
A nutrient medium has been developed to enable the growth of normal epithelial cells while selectively inhibiting fibroblast proliferation. In this medium, D-valine is substituted for L-valine; and only those cells containing D-amino acid oxidase can convert the D-amino acid
Hui Li et al.
PLoS pathogens, 14(1), e1006821-e1006821 (2018-01-05)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1 influenza
Ming Chen et al.
World journal of microbiology & biotechnology, 32(10), 171-171 (2016-08-28)
D-Valine is an important organic chiral source and has extensive industrial application, which is used as intermediate for the synthesis of agricultural pesticides, semi-synthetic veterinary antibiotics and pharmaceutical drugs. Its derivatives have shown great activity in clinical use, such as
V A Lazzaro et al.
Research communications in chemical pathology and pharmacology, 75(1), 39-48 (1992-01-01)
A selective cell culture medium, D-valine minimal essential medium (92 mg/l), has been developed to inhibit the proliferation of fibroblasts in cell culture (Gilbert & Migeon 1975). Substitution of D-valine for L-valine prevents fibroblast growth due to the absence of
Elham Mohammadi et al.
Cell and tissue research, 362(3), 597-609 (2015-06-13)
Efficacy of therapeutic angiogenesis needs a comprehensive understanding of endothelial cell (EC) function and biological factors and cells that interplay with ECs. Stem cells are considered the key components of pro- and anti-angiogenic milieu in a wide variety of physiopathological
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