T3434

Tyrphostin AG 490

solid

• Synonyme(s) : 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(benzyl)-2-propenamide, 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide
• Formule empirique (notation de Hill): C₁₇H₁₄N₂O₃
• Numéro CAS: 133550-30-8
• Poids moléculaire : 294.30
• Numéro MDL: MFCD00236452
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278732
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Pureté: ≥98% (HPLC)
• Forme: solid
• Couleur: yellow
• Solubilité: DMSO: soluble 10 mg/ml, clear, yellow; ethanol: 5 mg/mL; H₂O: insoluble
• Température de stockage: −20°C
• Chaîne SMILES: Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCc2ccccc2
• InChI: 1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
• Clé InChI: TUCIOBMMDDOEMM-RIYZIHGNSA-N
• Informations sur le gène: human ... EGFR(1956) , ERBB2(2064) , IL2(3558) , JAK2(3717)

Description

Application

Tyrphostin AG has been used to block IL-6 cytokine signaling to study its effects on glial cell reactivity⁵. AG 490 has also been used as a JAK2 inhibitor in human umbilical vein endothelial cells⁶.

Actions biochimiques/physiologiques

Jak-2 protein tyrosine kinase (PTK) inhibitor. Inhibits interleukin 2 (IL-2) driven mitogenesis and triggers apoptosis of tumor cells in Sezary syndrome, a leukemic variant of cutaneous T cell lymphoma.

Caractéristiques et avantages

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Attention

Photosensitive

Notes préparatoires

Tyrphostin AG 490 is soluble in ethanol at 5 mg/ml and is insoluble in water. It is also soluble in DMSO at 10 mg/ml and yields a clear, yellow solution.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3