SML1767
Sparstolonin B
≥98% (HPLC)
Synonyme(s) :
4,10-Dihydroxy-3H-pyrano[3,4,5-kl]xanthen-3-one, Sparstolenin B, SsnB
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About This Item
Formule empirique (notation de Hill):
C15H8O5
Numéro CAS:
Poids moléculaire :
268.22
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
≥98% (HPLC)
Forme
powder
Couleur
white to beige
Solubilité
DMSO: 10 mg/mL, clear
Température de stockage
2-8°C
Chaîne SMILES
OC(C=C1)=CC2=C1OC3=C4C(C(OC=C42)=O)=C(O)C=C3
Actions biochimiques/physiologiques
Potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties
Sparstolonin B (SsnB) is a polyphenol. It has a structural features similar to xanthone and isocoumarin. SsnB exerts anti-inflammatory properties on mouse and human macrophages. SsnB can significantly reduce hypoxia–reoxygenation-induced inflammation of cardiomyocytes by blocking extracellular signal-regulated protein kinase (ERK1/2) and c-jun N-terminal kinases (JNK) signaling pathways. Thus, SsnB acts as a potent therapeutic for the treatment of myocardial ischemia–reperfusion (MIR) injury.
Sparstolonin B (SsnB), an isocoumarin isolated from Sparganium stoloniferum and Scirpus yagara, is a potent TLR2 and TLR4 antagonist that exhibits anti-inflammatory and anti-viral (anti-HIV) properties. Sparstolonin B inhibits LPS induced inflammation in 3T3- L1 adipocytes, and reduces the body weight of rats fed with high fat diet. Sparstolonin B mitigates inflammation in nonalcoholic steatohepatitis (NASH) in mice model.
Mention d'avertissement
Warning
Mentions de danger
Conseils de prudence
Classification des risques
Eye Irrit. 2 - Skin Irrit. 2
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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Les clients ont également consulté
Xin Deng et al.
Virology journal, 12, 108-108 (2015-07-25)
The Chines herb derived Sparstolonin B, (SsnB), is a recently identified natural compound that selectively blocks TLR2- and TLR4-mediated inflammatory signaling. But it is unknown whether this compound has any effect on HIV infection. We found that SsnB treatment blocked
Ming Wang et al.
European journal of pharmacology, 769, 79-85 (2015-11-03)
Sparstolonin B (SsnB), an isocoumarin compound isolated from the tubers of both Sparganium stoloniferum and Scirpus yagara, has been reported to have anti-inflammatory effects. However, whether SsnB has anti-inflammatory effects on LPS-stimulated 3T3-L1 adipocytes remains unclear. In this study, we
Sparstolonin B attenuates hypoxia-reoxygenation-induced cardiomyocyte inflammation
Liu Q, et al.
Exp. Biol. Med, 239(3), 376-384 (2014)
Diptadip Dattaroy et al.
American journal of physiology. Gastrointestinal and liver physiology, 310(7), G510-G525 (2016-01-01)
Although significant research data exist on the pathophysiology of nonalcoholic steatohepatitis (NASH), finding an efficient treatment regimen for it remains elusive. The present study used sparstolonin B (SsnB), a novel TLR4 antagonist derived from the Chinese herb Sparganium stoloniferum, as
Characterization of Sparstolonin B, a Chinese Herb-derived Compound, as a Selective Toll-like Receptor Antagonist with Potent Anti-inflammatory Properties.
Liang Q, et al.
The Journal of Biological Chemistry, 286(30), 26470-26479 (2011)
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